C-C Bond formation:

Reactions  that  result  in  the  creation  of  ketones  by  carbon-carbon  bond formation are very significant since they can be employed to construct complex carbon skeletons from simple starting materials. Ketones can be synthesized from the reaction of acid chlorides along with organocuprate reagents, or from the reaction of nitriles with a Grignard or organolithium reagent. Aromatic ketones can be synthesized through the Friedel-Crafts acylation of an aromatic ring.

C-C Bond cleavage

Aldehydes  and  ketones  can  be  acquired  from  the  ozonolysis  of  appropriately substituted alkenes.