Integral membrane proteins

Membrane proteins are classified as either integral (intrinsic) or peripheral (extrinsic) depending on how tightly they are related with membrane. The  Integral membrane proteins are tightly bound to the membrane by interactions with the hydrophobic  core of the bilayer and can be extracted from them only through using agents which disrupt the membrane  structure, like as organic solvents such as chloroform  or detergents. Many integral proteins have one or more regions of the polypeptide chain which span the lipid bilayer and interact noncovalently with the hydrophobic fatty acid chains. Moreover, some are anchored in the membrane through a covalently attached fatty acid or hydrocarbon chain. Like as lipids, integral proteins are amphipathic that having both hydrophilic and hydrophobic regions, and are asymmetrically distributed across the bilayer.