Fluid mosaic model of membrane structure

In the year of 1972 Garth Nicholson and S.Jonathan Singer proposed the fiuid mosaic model   for   the   whole   structure   of   biological   membranes,   in   that   the membranes can be viewed as 2-D solutions of orientated lipids and globular proteins which is shown in the figure. The integral membrane proteins can be considered as icebergs fioating in a 2-D lipid ‘sea’.  They  proposed  which  the bilayer  industry  of the  lipids  would  act both  as a solvent  for the  amphipathic integral membrane proteins and as a permeability barrier. They also planned  that  some  lipids  should  interact  with  certain  membrane  proteins,  in which these interactions  would be essential  for the normal functioning  of the protein and that membrane proteins would be free to diffuse laterally in the plane of the bilayer  unless  restricted  in some way but would  not be able to fiip from one side of the bilayer to the other. This model is now supported through a broad variety of experimental observations.