Use of Mass spectrometric detectors:

Mass spectrometric detectors use computer control and data storage in real-time and computer reconstructed chromatograms. To achieve full benefit of an LC-MS combination, besides being low cost a mass spectrometer should have high sensitivity, high scan speed, adequate mass range and reasonable mass resolution. Time of flight mass spectrometers also have useful features such as unlimited mass range, high sensitivity, very high spectrum acquisition rate, multiplex detection capability.

Besides there are some detectors based on density, vapor pressure, heat of absorption, thermal and electrical conductivity measurements. Also, if the analyte sample has radioactive species formed as result of bombardment in a nuclear reactor then its radioactivity can be measured using nuclear detectors.

There are also special kinds of detectors based on spray impact, electron capture or transport which may measure electric charge in aerosol, absorption of electrons or isolating the sample followed by vaporization, respectively.