HDLs:

HDLs have the opposite function to that of LDLs in which they erased cholesterol from the tissues.  The HDLs are synthesized in the blood majorly from components derived from the degradation of other lipoproteins.  HDLs  then  obtain their  cholesterol  through  extracting  it from  cell  membranes  and  converting  it into cholesterol esters through the action of LCAT described in the figure. The HDLs are then either taken up straightly via the liver or transfer their cholesterol esters to VLDLs, of that about half are taken up through the liver via receptor-mediated endocytosis shown in the figure. The liver is the only organ which can dispose of significant quantities of cholesterol and primarily in the form of bile salts.