Chylomicrons Assignment Help

Assignment Help: >> Lipoproteins - Chylomicrons

Chylomicrons:

Chylomicrons, the widest of the lipoproteins, are synthesized in the intestine. They carrying ingested triacylglycerols to other tissues, majorly skeletal muscle and adipose tissue and transport ingested cholesterol to the liver described in the figure. At the goal tissues the triacylglycerols are hydrolyzed through the action of lipoprotein lipase, an enzyme situated on the outside of the cells which is activated through apoC-II, one of the apoproteins on the chylomicron surface. The released monoacylglycerols  and fatty acids are  taken  up  through  the  tissues  and  either  used  for  energy.

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Figure:   The transport of triacylglycerol and cholesterol by lipoproteins.

production or re-esterified  to triacylglycerol  for storage. Because their triacylglycerol content is depleted, the chylomicrons shrink and create cholesterol-rich chylomicron remnants that are transported in the blood to the liver described in the figure. At this time they bind to a specific cell-surface remnant receptor and are taken up into the liver cells through receptor-mediated endocytosis.

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