Disadvantages:

Besides so many advantages, the method also suffers from many disadvantages as given below:

i) It cannot be used for the analysis of volatile compounds such as hydrocarbons.

ii) It cannot be used for the analysis of industrial products such as alloys, polymers etc.

iii) High purity solvents are required because any impurity may affect the separation and resolution.

iv) It requires extensive training in order to operate the instrument and optimize the conditions.

v) Sample preparation is often required e.g. dissolution, dilution, etc