Gluconeogenesis pathway Assignment Help

Assignment Help: >> Gluconeogenesis - Gluconeogenesis pathway

Gluconeogenesis pathway:

In glycolysis the glucose is metabolized to pyruvate. In the gluconeogenesis, pyruvate is metabolized to glucose. Therefore, in principle, gluconeogenesis appears to be a reversal of glycolysis.  Indeed,  some  of the  reactions  of glycolysis  are reversible  and  so  the  two  pathways  have  these  steps  in  common.  Moreover,

446_Gluconeogenesis pathway.png

Figure: Comparison of gluconeogenesis and glycolysis. The three steps of glycolysis that are irreversible are numbered. (1) Hexokinase  in glycolysis is reversed by glucose 6-phosphatase in gluconeogenesis;  (2) PFK in glycolysis is reversed by fructose 1,6-bisphosphatase in gluconeogenesis;  (3) pyruvate kinase in glycolysis is reversed by two sequential reactions in gluconeogenesis catalyzed by pyruvate carboxylase and PEP carboxykinase.

three steps in glycolysis are essentially irreversible; those catalyzed through the enzymes hexokinase, PFK (phosphofructokinase) and pyruvate kinase. Indeed it is the huge negative free-energy change in these reactions that usually drives glycolysis forward towards pyruvate formation. Therefore in the gluconeogenesis these three steps have to be reversed through using other reactions as shown in Figure; gluconeogenesis is not an easy reversal of glycolysis.

Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd