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Hormonal control by insulin:Insulin is released into the bloodstream through the β cells of the pancreas when blood glucose stages are high after feeding and stimulates glycogen synthesis to store excess glucose as glycogen. This organize is also achieved through phosphorylation events. Insulin connecting to its receptor in the plasma membrane and activates it. This receptor has tyrosine kinase movement example for it will phosphorylate selected tyrosine residues on target proteins. Its activation leads to the activation of an insulin-responsive protein kinase in which then phosphorylates protein phosphatase I, therefore activating it. This enzyme now ensures that glycogen synthase is dephosphorylated and therefore active and which phosphorylase kinase is also dephosphorylated (and thus inactive). The net effect is to stimulate glycogen synthesis.
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