Allosteric control and covalent modification:
Phosphorylase exists in two interchangeable forms that are; active phosphorylase a and a commonly inactive phosphorylase b. A Phosphorylase b is a dimer and is converted into phosphorylase a through phosphorylation of a one serine residue on each subunit through the enzyme phosphorylase kinase. The procedure can be reversed and phosphorylase inactivated through removal of the phosphate group through protein phosphatase I shown in the figure.
![](https://expertsmind.com/cms/data:image/png;base64,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)
Figure: Regulation of (a) glycogen phosphorylase activity and (b) glycogen synthase activity by phosphorylation (covalent modification).
In skeletal muscle and high concentrations of AMP can activate phosphorylase b (through acting at an allosteric site) but this is opposed via the concentrations of ATP and glucose 6-phosphate establish in resting muscle so which in this condition phosphorylase b is indeed inactive. Because most of the phosphorylase in resting muscle is phosphorylase b and significant glycogen degradation does not occur under these conditions. Moreover, during exercise, the concentrations of ATP and glucose 6- phosphate fall and the concentration of AMP increase. Therefore phosphorylase b becomes activated and this leads to the rapid degradation of glycogen to yield energy as needed. Phosphorylase a is unaffected through ATP and AMP or glucose 6- phosphate and so remains active under all conditions.
In liver, phosphorylase b is not activated through AMP and is thus always inactive. Unlike muscle, thus, glycogen degradation in liver is not responsive to the energy status of the cell. Rather, phosphorylase a is deactivated through glucose. This fits with the variant role of glycogen storage in liver which is namely to maintain blood levels of glucose. Therefore as glucose levels increased, glycogen degradation through liver phosphorylase a is shut off and degradation begins again only as the glucose level falls.
Glycogen synthase is also regulated through covalent modification and allosteric interactions. The enzyme live as an active glycogen synthase a and a commonly inactive glycogen synthase b. Moreover, in compare to phosphorylase it is the active form of glycogen synthase (synthase a) which is dephosphorylated while the inactive synthase b form is the phosphorylated form described in the figure.
A high concentration of glucose 6-phosphate can activate glycogen synthase b. In during muscle contraction glucose 6-phosphate levels are low and thus glycogen synthase b is inhibited. This is at the period of time when phosphorylase b is most active. Therefore glycogen degradation happens and glycogen synthesis is inhibited, avoiding the operation of a futile cycle. When the muscle revisit to the resting state and ATP and glucose 6-phosphate levels increased, phosphorylase b is inhibited and turning off glycogen degradation, while glycogen synthase is activated to rebuild glycogen reserves. The synthase a structure is active irrespective of the concentration of glucose 6- phosphate.