Bile salts:
Bile salts or bile acids are polar derivatives of constitute and cholesterol the main pathway for the excretion of cholesterol in mammals. In the liver, the cholesterol is transformed into the activated intermediate cholyl CoA that then reacts either with the amino set of glycine to form glycocholate shown in the above figure or with the amino group of taurine (H2N-CH2 -CH2 -SO3 -, a derivative of cysteine) to create taurocholate. Once synthesis in the liver the bile salts taurocholate and glycocholate are stored and concentrated in the gall bladder, earlier than release into the small intestine. Still they hold both nonpolar and polar regions (which is amphipathic molecules), the bile salts are extremely effective detergents and act to solubilize dietary lipids. The concluding increase in the surface area of the lipids aids their hydrolysis through lipases and their uptake into intestinal cells. The intestinal absorption of the lipid-soluble vitamins A, D, E and K also want the action of the bile salts.