The Zeisel determination or Zeisel test is an organic test for the presence of esters or ethers in a chemical substance. It is named for the Czech chemist Simon Zeisel (1854-1933). In a qualitative test a sample is initially reacted with a mixture of acetic acid and hydriodic acid in a test tube. The ensuing reaction resulting in the cleavage of the ether or the ester into an alkyl iodide and correspondingly an alcohol or an carboxylic acid.
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