The Mannich reaction is a chemical organic reaction which comprise of an amino alkylation of an acidic proton placed next to a carbonyl functional group with formaldehyde and ammonia or any primary or secondary amine. The end product is a β-amino-carbonyl compound also called as a Mannich base. Reactions among aldimines and α-methylene carbonyls are also called as Mannich reactions because these imines form between amines and aldehydes. The reaction is named for the chemist Carl Mannich.
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