The Lossen rearrangement is the change of a hydroxamic acid (1) to an isocyanate (3) through the formation of an O-acyl, sulfonyl, or phosphoryl intermediate hydroxamic acid O-derivative (2) and then change to its conjugate base. Here, 4-Toluenesulfonyl chloride is used to give a sulfonyl O-derivative of hydroxamic acid.
![1136_Lossen-rearrangement.png](https://www.expertsmind.com/../CMSImages/1136_Lossen-rearrangement.png)
Reaction Mechanism-
![1441_Lossen-rearrangement-mechanism.png](https://www.expertsmind.com/../CMSImages/1441_Lossen-rearrangement-mechanism.png)
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