The Liebeskind-Srogl coupling reaction is a chemical reaction producing a new carbon-carbon bond from a thioester and a boronic acid using a metal catalyst. The metal catalyst shown below uses TFP = tris(2-furyl)phosphine as an supplementary ligand and CuTC = copper(I) thiophene-2-carboxylate as a co-metal catalyst. The general reaction scheme is shown below.
Reaction Mechanism-
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