The Fischer indole synthesis is an organic reaction that makes the aromatic heterocycle indole from a (substituted) phenylhydrazine and an aldehyde or ketone under acidic conditions. The reaction was founded in 1883 by Hermann Emil Fischer. Nowadays antimigraine drugs of the triptan class are frequently synthesized by this method.
![1808_Fischer-indole-synthesis.png](https://www.expertsmind.com/CMSImages/1808_Fischer-indole-synthesis.png)
Mechanism of Reaction -
![1065_Fischer-indole-synthesis-mechanism.png](https://www.expertsmind.com/../CMSImages/1065_Fischer-indole-synthesis-mechanism.png)
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