The Eschweiler-Clarke reaction (also referred to as Eschweiler-Clarke methylation) is a chemical reaction wherein a primary (or secondary) amine is methylated utilising excess formic acid and formaldehyde. Reductive amination reactions like this one will not make quaternary ammonium salts, but in its place will stop at the tertiary amine stage. It is named after German chemist Wilhelm Eschweiler (1860-1936) and the British chemist Hans Thacher Clarke (1887-1972).
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