The Duff reaction or hexamine aromatic formylation is a formylation reaction utilized in organic chemistry for the production of benzaldehydes with hexamine as the formyl carbon source. It is named on the chmeist James Cooper Duff, worked at the College of Technology, Birmingham, roughly 1920-1950.
Illustration is the synthesis of 3,5-di-tert-butylsalicylaldehyde:
![283_Duff-reaction.png](https://www.expertsmind.com/../CMSImages/283_Duff-reaction.png)
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