Regulation of Transcription by RNA:

In the eukaryotes, transcription of the diverse array of tens of thousands of protein-coding genes is holed out through RNA polymerase II. The control of this procedure is predominantly mediated through a network of thousands of sequence-specific DNA binding transcription factors which interpret the genetic regulatory information, like as in transcriptional promoters and enhancers, and transmit the appropriate response to the RNA polymerase II transcriptional machinery. This review will elaborate some early advances in the discovery and characterization of the sequence-specific the DNA binding transcription factors as well as some of the properties of these regulatory proteins.

Eukaryotic RNA polymerase II pol II is a 12-subunit DNA-dependent RNA polymerase which is responsible for transcribing nuclear genes encoding messenger RNAs and various little nuclear RNAs 1. Regardless it's obvious structural complexity, this multisubunit enzyme needs two groups of auxiliary proteins to explain two critical biochemical problems. The First one is, pol II cannot recognize its goal promoters directly. And second one, pol II must be able to modulate production of the RNA transcripts of individual genes in response to environmental and developmental signals.