Isotope Dilution Analysis (IDA):

It is a widely used quantitative analytical technique of considerable value in complex mixtures of compounds in organic syntheses, biochemical systems and for the determination of inorganic elements in geological and biological samples. It was first developed by George de von Hevesy and R. Hobbie in the year of 1932 though many innovative developments were made through J. Ruzicka. J. Tolgyessy, and J. Stary. It has the advantage of not requiring the separation of a component to be determined quantitatively from an analyte mixture. The technique of IDA has two alternatives, direct isotope dilution analysis (DIDA) and inverse/reverse isotope dilution analysis (I/RIDA).