Amino acid degradation:
As there is no store for excess amino acids, and as proteins are constantly being turned over, amino acids have to be repeatedly degraded. The α-amino group is erased first and the resulting carbon skeleton is transformed into one or more main metabolic intermediates and used as metabolic fuel. The carbon skeletons of the 20 standard amino acids are funneled into only seven molecules that are as follows: acetoacetyl CoA, pyruvate, succinyl CoA, acetyl CoA, α-ketoglutarate, oxaloacetate and fumarate. Amino acids which are degraded to pyruvate, succinyl CoA, α-ketoglutarate, oxaloacetate and fumarate are termed glucogenic as they can produce increse to the net synthesis of glucose. This is just because the citric acid cycle intermediates and pyruvate can be transformed into phosphoenolpyruvate and then into glucose through gluconeogenesis. By comparison amino acids that are degraded to acetyl CoA or acetoacetyl CoA are termed ketogenic since they produce rise to ketone bodies; the acetyl CoA or acetoacetyl CoA can also be used to synthesize lipids. Of the standard set of 20 amino acids, only Lys and Leu are solely ketogenic. Phe, Trp Ile, and Tyr are both ketogenic and glucogenic as some of their carbon atoms end up in acetyl CoA or acetoacetyl CoA, while others end up in precursors of glucose and the remaining 14 amino acids are classified as solely glucogenic.