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What is Translocation?
Sometimes pieces of two chromosomes that are not homologous break off at the same time. If the broken pieces are re-attached to the opposite (in this case the non-homologous) chromosomes, the result is a translocation, as seen below.
The best known example of a translocation is the Philadelphia chromosome. This is simply chromosome number 22 that has lost a portion in exchange a small portion of chromosome number 9. This chromosome is named after the city where the abnormality was first discovered, and is responsible for causing chronic myelogenous leukemia.
explain the lock and key theory
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