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In Chemical Reactions that have a large negative /\Go'
a- the total amount of both reactants and products decreases
b- the products are less stable than the reactants
c- there is a large excess of products to reactants when the reaction reaches equilibrium
d- the activation energy is always very low
Whenever a chromosome is replicated the replication machinery passes by the nucleosomes without deleting the histones from the DNA. How this happens is since not fully understood.
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