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What is the clinical deficiency presented by hemophilic people? What is the genetic cause of that deficiency?
The Hemophilia is a disease characterized by impaired blood clotting and the affected person is more prone to internal and external hemorrhages.
The Patients with hemophilia A have alteration in the gene that codifies the factor VIII of blood clotting a gene located in the non-homologous portion of the X chromosome. The Patients with hemophilia B present a defect of the gene that codifies the factor IX of clotting, a gene also located in the non- homologous region of the X chromosome. Therefore both diseases are X- linked diseases.
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