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Q. What is Rounded ST Depression?
A rounded ST-segment depression pattern in the CM5 lead, as well as in the other leads, is common and is often associated with ischaemia. This pattern is somewhat difficult to evaluate if the duration of the ST-segment sagging is very short, but it usually reflects ventricular dysfunction. This pattern is associated with slightly increased incidence of subsequent coronary events. Patients with a rounded pattern had a 5.8 per cent per year incidence of coronary events, compared with 8.3 per cent per year for those with a horizontal pattern.
This technique utilizes an enzyme resolvase, endo vii, cloned from the bacteriophage t4. This enzyme has high specificity to find deletions, insertions, and base substitutions muta
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