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In at least single eukaryote, Tetrahymena, the pre-rRNA molecule holds an intron. Erasing of the intron in running processing of the pre-rRNA does not require the assistance of any protein! Instead, in the presence of guanosine, GDP, GMP or GTP, the intron excises itself is a phenomenon known as self- splicing. This was the first expression of ribozymes, which is, catalytic RNA molecules which catalyze particular reactions. The Self-splicing introns have also been discovered in some eukaryotic mRNAs and even peptidyl transferase a main activity in protein synthesis is now known to be a ribozyme.
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Define Metabolic Aberrations and Clinical Manifestations? The state of obesity brings about certain alterations in the normal body processes which are enumerated herewith and h
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