What is protein denaturation, Biology

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What is protein denaturation? Is there any change in the primary structure when a protein is denatured?

Secondary, tertiary and quaternary structures of proteins are spatial structures. Denaturation is changing in any of these spatial structures that make the protein lacking or biologically inactive.

After denaturation the primary protein structure is not affected.

Protein Structure Review - Image Diversity: denatured protein

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