What is hemoglobin releasing hormone, Biology

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In a red blood cell, which of the following will lead to a reduction in the percentage of hemoglobin that has oxygen bound to it?

A. A decrease in the amount of HbRH (Hemoglobin Releasing Hormone) that is bound to HbRH Receptors in the plasma membrane of the red blood cell.

B. A reduction in the concentration of dissolved oxygen in the red blood cell.

C. An enhance in the concentration of hydrogen ions in the red blood cell

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