What is dyslipidaemia, Biology

Assignment Help:

What is Dyslipidaemia ?

The results of epidemiological studies, as well as trials with angiographic or clinical endpoints, confirm the importance of various lipid fractions in the pathogenesis of atherosclerosis. There is a strong and graded positive association between total and LDL cholesterol and risk of vascular events (mainly ischaemic heart disease) extending over a wide range of cholesterol concentrations. This association applies to individuals with or without established CAD as well as to women and men. Other risk factors can substantially aggravate the effects of LDL cholesterol.

The other fraction of the lipid is HDL cholesterol. It is also called 'good' cholesterol as there is a strong and inverse association between HDL cholesterol and the risk of CAD in both men and women and in subjects with or without established CAD; the lower the concentration of HDL-cholesterol the greater the risk of CAD. The inverse association between HDL-cholesterol levels and CAD risk at least equals the positive association between CAD risk and serum LDL cholesterol events. There is now evidence from the Veterans Administration High density Lipoprotein Cholesterol Intervention Study (VA-HIT) that the increase in HDL-cholesterol in CAD patients is followed by a significant decrease in major coronary events.

Triglycerides are the other lipid components in the blood 2nd they also contribute to an increased risk of coronary artery disease by a number of mechanisms. The triglyceride rich lipoproteins may be independently atherogenic or they may promote atherosclerosis by inducing a procoagulant state and promoting thrombosis.

While level of individual lipid factor may be important in the pathogenesis of coronary atheroclerosis, interplay of different lipid fractions is much more significant. For example, at a given level of LDL cholesterol, the atherogenic potential is enhanced in presence of low HDL cholesterol level. Again, the ratio of total cholesterol (TC) to HDL cholesterol (HDLc) emerges as the most powerful predictor of atherosclerosis; a TC/HDLc ratio more than 4,5 is associated with high risk of CAD.

 


Related Discussions:- What is dyslipidaemia

Assessment of tubercular meningitis, Assessment   For assessment of cli...

Assessment   For assessment of clinical manifestation of the disease you need to understand three stages of clinical course of the disease which are as follows:  Prodromal

How athletes benefit from consuming high carbohydrate foods, How Athletes b...

How Athletes benefit from consuming high carbohydrate foods? Athletes benefit from consuming high carbohydrate foods immediately after ending repeated intervals of intense exer

What is choanoflagellate. explain in brief., What is Choanoflagellate? Expl...

What is Choanoflagellate? Explain in brief. The protozoans which resemble the choanocyte cells found in sponges. They have a collar of microvilli which surround a central flage

Significance of mitosis, Significance of Mitosis 1.      Reproduction ...

Significance of Mitosis 1.      Reproduction ;   William Bateson 1906 wrote, Whenever  I observe a dividing  cell under  the  microscope , I feel  as if the original act of  c

Entomophily - cross-pollination, Entomophily - Cross-pollination It in...

Entomophily - Cross-pollination It involves insects to carry the pollen to achieve pollination. Salvia exhibits a specialised 'tumapipe' floral mechanism that signifies classi

Is there respiratory pigment in the annelid blood, Q. Is there respiratory ...

Q. Is there respiratory pigment in the annelid blood? The blood in beings of the phylum Annelida contains the respiratory pigment hemoglobin the same found in chordates and oth

Explain about harvesting autogenous bone grafts, What are the precautions t...

What are the precautions to be taken when harvesting autogenous bone grafts from mandibular symphysis and ramus? When harvesting grafts from the mandibular symphysis region, fo

Explain the process of biosynthetic phase, Describe the process of biosynth...

Describe the process of biosynthetic phase of photosynthesis occurring in the chloroplast. Explain the process of development of root nodules in a leguminous plant. Name the ox

Malnutrition related diabetes mellitus, Q. Explain about Malnutrition Relat...

Q. Explain about Malnutrition Related Diabetes Mellitus? This type of diabetes has been categorized as a separate entity. 'if is 'Men seen commonly in developing countries, 1n

What are genotypes and respective blood types of abo system, What are the g...

What are the genotypes and respective blood types of the ABO system? Ever since the alleles are IA, IB and i the possible genotypes are IAIA (blood type A), IAIB (blood type AB

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd