What is dyslipidaemia, Biology

Assignment Help:

What is Dyslipidaemia ?

The results of epidemiological studies, as well as trials with angiographic or clinical endpoints, confirm the importance of various lipid fractions in the pathogenesis of atherosclerosis. There is a strong and graded positive association between total and LDL cholesterol and risk of vascular events (mainly ischaemic heart disease) extending over a wide range of cholesterol concentrations. This association applies to individuals with or without established CAD as well as to women and men. Other risk factors can substantially aggravate the effects of LDL cholesterol.

The other fraction of the lipid is HDL cholesterol. It is also called 'good' cholesterol as there is a strong and inverse association between HDL cholesterol and the risk of CAD in both men and women and in subjects with or without established CAD; the lower the concentration of HDL-cholesterol the greater the risk of CAD. The inverse association between HDL-cholesterol levels and CAD risk at least equals the positive association between CAD risk and serum LDL cholesterol events. There is now evidence from the Veterans Administration High density Lipoprotein Cholesterol Intervention Study (VA-HIT) that the increase in HDL-cholesterol in CAD patients is followed by a significant decrease in major coronary events.

Triglycerides are the other lipid components in the blood 2nd they also contribute to an increased risk of coronary artery disease by a number of mechanisms. The triglyceride rich lipoproteins may be independently atherogenic or they may promote atherosclerosis by inducing a procoagulant state and promoting thrombosis.

While level of individual lipid factor may be important in the pathogenesis of coronary atheroclerosis, interplay of different lipid fractions is much more significant. For example, at a given level of LDL cholesterol, the atherogenic potential is enhanced in presence of low HDL cholesterol level. Again, the ratio of total cholesterol (TC) to HDL cholesterol (HDLc) emerges as the most powerful predictor of atherosclerosis; a TC/HDLc ratio more than 4,5 is associated with high risk of CAD.

 


Related Discussions:- What is dyslipidaemia

Primary succession - community change, Primary Succession - Community Chang...

Primary Succession - Community Change In primary succession on a terrestrial site the new site is first colonised by a few hardy pioneer species that are often microbes, liche

What do you mean by taxonomist, Q. What do you mean by Taxonomist? Mode...

Q. What do you mean by Taxonomist? Modern classification systems are based on many types of evidence. A truly natural classification is obtained from analysis and harmonisation

State long-term benefits of exercise, State four long-term benefits of exer...

State four long-term benefits of exercise. The long-term advantages of exercise are: a) Enhance in size of the muscles used, b) Decrease of heart rate and c)  Enhance

State in brief about the soil horizon, State in brief about the soil horizo...

State in brief about the soil horizon A  soil horizon may be defined as "a horizontal layer of regolith, approximately parallel to the soil surface, and possessing relatively

Biothw, Determine sequence weights for the sequences ACTA, ACTT, CGTT, and ...

Determine sequence weights for the sequences ACTA, ACTT, CGTT, and AGAT in problem 1 by using Thompson, Higgins, and Gibson method

Describe directly and indirectly modes of transcription , 1.  A completely ...

1.  A completely new protein has been synthesized by a research lab. You are inadvertently exposed to it and have an allergic response. What type of antibody initiates this respons

What is the spontaneous generation hypothesis, What is the spontaneous gene...

What is the spontaneous generation hypothesis? The spontaneous generation hypothesys, or abiogenesis, asserts that life on earth has come from nonliving material. For instance,

Explain about the food product development, Explain about the Food product ...

Explain about the Food product development? Food product development is often commodity related. This type of research needs to be carried out in the pilot plants with the equi

What is the main theory opposed to evolution, What is the main theory oppos...

What is the main theory opposed to evolution? The major theory that opposes the evolution theory on the description of how species emerged (phylogenesis) is fixism.

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd