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Bone Modeling
It is a surface-specific activity (apposition or resorption) that produces a net change in the size and/or shape of a bone after initial bone formation in the embryonic or initial healing stage . It is an uncoupled process , that is bone structure alterations occur by independent action of osteoblasts and osteoclasts. Modeling represents a process that allows a change in initial bone architecture. It has been suggested that external demands such as load may initiate modeling. Therefore, it means that bone resorption and formation occur on different surfaces.
While various positive control components lie close to the gene they regulate additional can be situated long distances away (sometimes 10-50 kb) either upstream or downs
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