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Bone Modeling
It is a surface-specific activity (apposition or resorption) that produces a net change in the size and/or shape of a bone after initial bone formation in the embryonic or initial healing stage . It is an uncoupled process , that is bone structure alterations occur by independent action of osteoblasts and osteoclasts. Modeling represents a process that allows a change in initial bone architecture. It has been suggested that external demands such as load may initiate modeling. Therefore, it means that bone resorption and formation occur on different surfaces.
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Phenylketonuria is a severe form of mental disability caused by a homozygous recessive allele. The condition affects about 1 in 10,000 neborn Caucasians. Estimate the frequency of
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