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Q. What do you mean by neurotransmitters?
- Nicotinic receptors (nicotine mimics the effects of Ach here). Found at NM-junction, ANS ganglions in general. Binding of Ach to nicotinic receptors is always excitatory (e.g. skeletal muscle contraction).
- Muscarinic receptors occur on all effector cells stimulated by the parasympathetic system. Effect of Ach on muscarinic receptors may be excitatory or inhibitory depending on target organ.
ACh -> (-) heart myocardium, however, ACh -> (+) GI tract smooth muscle
ACh is normally destroyed by ACh-ase, a degradative enzyme found on post-synaptic cells.
Nerve gas is a potent inhibitor of Ach-ase activity -> magnifies cholinergic effects, however, less potent is neostigmine (used in the treatment of myasthenia gravis).
Atropine is a reversible blocker of ACh used in cardiac rescucitation (blocks acetylcholine; so stimulates heart beat).
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