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Q. What are the major theoretical models that try to explain the formation of the enzyme-substrate complex?
There are two major models that explain the formation of the enzyme-substrate complex: the key and lock model and the induced fit model. In the key and lock model the enzyme has a region with specific spatial conformation for the binding of the substrate. In the induced fit model the binding of the substrate induces a alteration in the spatial configuration of the enzyme for the substrate to fit.
These are safe and free of systemic side effects. However, gastrointestinal side effects are common, and compliance is poor. The average LDL decreases by approximately 15 per cent
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working of pcr
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