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In glycoproteins, two main parts of oligosaccharide linkages exist:
a) An O-linked oligosaccharides attached to the protein by O-glycosidic bonds, to the OH groups of serine or threonine side-chains.
b) An N-linked oligosaccharides attached to the protein by N-glycosidic bonds to the NH2 collections of asparagine side-chains.
1. Using specific examples describe how variations in DNA sequence between individuals can lead to risk of disease. Describe how a range of techniques have been adapted to detect s
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