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Simple diffusion
Only comparatively small uncharged or hydrophobic molecules (H2O, O2, and CO2, other gases, urea and ethanol) cross the lipid bilayer through simple diffusion. Membrane proteins are not included, so there is no specificity. The molecule in aqueous solution on single side of the membrane dissolves into the lipid bilayer crosses it and then dissolves into the aqueous solution on the other side. The rate of diffusion is straight proportional to the concentration gradient of the molecule across the membrane and the procedure is not saturable.
Facilitated diffusion
Not like simple diffusion the facilitated or carrier-mediated diffusion of a molecule across a biological membrane is dependent on specific integral membrane
figure: Kinetics of (a) simple and (b) facilitated diffusion
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