Tumor suppressor genes, Biology

Assignment Help:

Tumor Suppressor Genes

Tumor suppressor genes or anti-oncogenes generally inhibit cell division in cooperation with proto-oncogenes. The very existence of these genes prevents cells from undergoing neoplastic transformation. While tumor suppressor genes are inactivated by mutations or are deleted, the absence of their protein products permits malignant growth to occur. The most extensively studied disease caused through suppressor genes is the childhood tumor retinoblastoma (cancer of the retina). The gene included is Rb and the genotype of normal individuals is Rb/Rb. A prerequisite of tumor creation is the development of homozygosity or heterozygosity of the rb allele. The possible genetypes for retinoblastoma are, hence, rb/rb; rb/- or -/-


Related Discussions:- Tumor suppressor genes

Explain some limitations of most probable number, Explain some Limitations ...

Explain some Limitations of Most Probable Number? 1. Large quantity of glassware is required. 2. Colony morphology cannot be determined. 3. It lacks precision.

Echocardiography, Both global and regional systolic function are to be chec...

Both global and regional systolic function are to be checked. Global measures include ejection fraction, stroke volume, end systolic volume. (For measurement of systolic function u

What is the diffusion, Q What is the diffusion? Diffusion is the spread...

Q What is the diffusion? Diffusion is the spreading of substance molecules from a region where the substance is further more concentrated to another region where it is less con

Aleurone grains, ALEURONE GRAINS - Also known as Plant lysosome , beca...

ALEURONE GRAINS - Also known as Plant lysosome , because they contain hydrolytic enzymes. Consists of Proteins. They are also known as Aleuroplast because they are ric

Ross operation-surgical techniques, Ross Operation :  In this technic...

Ross Operation :  In this technically demanding operation, the aortic valve is replaced by patient's own pulmonary valve (autograft) and a pulmonary or aortic allograft (homo

State about the halsted reitan battery, State about the Halsted Reitan batt...

State about the Halsted Reitan battery The Halsted Reitan battery, as the procedure came to be known over the years, also has a history. It has been described as a fixed batter

How does the excretory system of nematodes work, How does the excretory sys...

How does the excretory system of nematodes work? The metabolic residuals of nematodes are collected by two longitudinal lateral excretory channels that open in one excretory po

What is blood typing?, What is blood typing? The Blood typing is the de...

What is blood typing? The Blood typing is the determination, by means of tests, of the classification of a blood sample concerning blood group systems (specially the Rh system

How genetic material is transmitted, Name two differences how genetic mater...

Name two differences how genetic material is transmitted between prokaryotes (bacteria) and eukaryotes (humans). Hint: consider the number and structure of the chromosomes, the num

What is nerve impulses in human biology, What is Nerve Impulses in human bi...

What is Nerve Impulses in human biology? A nerve impulse is an electrical signal carried by a nerve cell. Unlike electrical transmission in wires, this impulse is non-decremen

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd