Tumor suppressor genes, Biology

Assignment Help:

Tumor Suppressor Genes

Tumor suppressor genes or anti-oncogenes generally inhibit cell division in cooperation with proto-oncogenes. The very existence of these genes prevents cells from undergoing neoplastic transformation. While tumor suppressor genes are inactivated by mutations or are deleted, the absence of their protein products permits malignant growth to occur. The most extensively studied disease caused through suppressor genes is the childhood tumor retinoblastoma (cancer of the retina). The gene included is Rb and the genotype of normal individuals is Rb/Rb. A prerequisite of tumor creation is the development of homozygosity or heterozygosity of the rb allele. The possible genetypes for retinoblastoma are, hence, rb/rb; rb/- or -/-


Related Discussions:- Tumor suppressor genes

Noise pollution, Sound is a main mean of communication and entertainment an...

Sound is a main mean of communication and entertainment and is also very effective alarm system for some animal. A loud and unwanted or unpleasant sound causes discomfort and is ca

What is nervous system, What is Nervous System? The nervous system is m...

What is Nervous System? The nervous system is made up of associations of cells called neurons. Bundles of neurons are called nerves. The nervous system is divided into two part

Endocrine glands - prostaglandins, PROS T AGLANDIN S (PGS) - Beca...

PROS T AGLANDIN S (PGS) - Because they were first found in semen (which is produced partly by the prostate gland), they were named prostaglandins. Prostaglandins are d

Cells, what happens in meiosis in prophase 1?

what happens in meiosis in prophase 1?

Legal rights of psychiatric patients, LEGAL RIGHTS OF PSYCHIATRIC PATIENTS:...

LEGAL RIGHTS OF PSYCHIATRIC PATIENTS: When a patient is admitted in psychiatric hospital he may be deprived of  the freedom  to leave the hospital, and also to maintain certai

Cleft palate, Cleft Palate   Well you have now learnt about the cleft l...

Cleft Palate   Well you have now learnt about the cleft lip and now let us discuss and understand what is cleft palate. Cleft palate (CP) is midline fissure of  the palate that

Class Pisces, need different types of information about fishes and their pi...

need different types of information about fishes and their pictures

Compare the modes of intercellular communication, Compare the modes of inte...

Compare the modes of intercellular communication used by the endocrine and nervous systems and discuss the functional significance of the differences between the two systems.

Physiology of the heart, The heart is the muscular pump that pushes blood t...

The heart is the muscular pump that pushes blood through the circulatory system. Each heartbeat can be felt as an arterial pulse. The heart valves when closed prevent the blood fro

How to calculate the net protein utilization (npu), How to calculate the Ne...

How to calculate the Net Protein Utilization (NPU)? Mitchell (1922) introduced the term 'Net Utilization of Dietary Protein' which is a product of digestibility coefficient and

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd