Tumor suppressor genes, Biology

Assignment Help:

Tumor Suppressor Genes

Tumor suppressor genes or anti-oncogenes generally inhibit cell division in cooperation with proto-oncogenes. The very existence of these genes prevents cells from undergoing neoplastic transformation. While tumor suppressor genes are inactivated by mutations or are deleted, the absence of their protein products permits malignant growth to occur. The most extensively studied disease caused through suppressor genes is the childhood tumor retinoblastoma (cancer of the retina). The gene included is Rb and the genotype of normal individuals is Rb/Rb. A prerequisite of tumor creation is the development of homozygosity or heterozygosity of the rb allele. The possible genetypes for retinoblastoma are, hence, rb/rb; rb/- or -/-


Related Discussions:- Tumor suppressor genes

What do you mean by ventricular arrhythmias, Q. What do you mean by Ventric...

Q. What do you mean by Ventricular Arrhythmias? Considerable disagreement exists regarding the significance of resting ventricular ectopic beats. In study comparing the coronar

Spermatogonia - spermatozoa, Normal 0 false false false ...

Normal 0 false false false EN-IN X-NONE X-NONE MicrosoftInternetExplorer4 Spermatogonia - Spe

Are body planes important for identifying structure, Q. Are body planes imp...

Q. Are body planes important for identifying anatomical structure? In order to observe and study structural arrangement of the internal organs, body may be divided and sectione

Preparation of patient for fasting blood sugar analysis, Preparation of Pat...

Preparation of Patient for Fasting Blood Sugar Analysis 1. Blood for fasting blood sugar (plasma glucose) analysis should be drawn after the individual has fasted overnight (8-

What is the structural depiction of a carboxyl group, Q. What is the struct...

Q. What is the structural depiction of a carboxyl group? Carboxyl groups have a carbon attached to one hydroxyl group by a simple bond and one oxygen by a double bond. The othe

What is obesity in biochemical or physiological risk, What is Obesity in bi...

What is Obesity in biochemical or physiological risk ? Obesity results from a complex interaction of genetic predisposition and environmental factors operating throughout an in

Explain complete and incomplete digestive system , Normal 0 fal...

Normal 0 false false false EN-IN X-NONE X-NONE MicrosoftInternetExplorer4

Obesity a health hazard, Obesity a health hazard: The factors of obe...

Obesity a health hazard: The factors of obesity are complex. Obesity is due to over eating and excess of energy intake. The obese child when grows up will be a target

How can the enzymes be classified, How can the enzymes be classified? Expla...

How can the enzymes be classified? Explain giving examples. Based on structure, enzymes can be classified into monomeric enzymes and oligomeric compounds. Monomeric enzym

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd