Tumor suppressor genes, Biology

Assignment Help:

Tumor Suppressor Genes

Tumor suppressor genes or anti-oncogenes generally inhibit cell division in cooperation with proto-oncogenes. The very existence of these genes prevents cells from undergoing neoplastic transformation. While tumor suppressor genes are inactivated by mutations or are deleted, the absence of their protein products permits malignant growth to occur. The most extensively studied disease caused through suppressor genes is the childhood tumor retinoblastoma (cancer of the retina). The gene included is Rb and the genotype of normal individuals is Rb/Rb. A prerequisite of tumor creation is the development of homozygosity or heterozygosity of the rb allele. The possible genetypes for retinoblastoma are, hence, rb/rb; rb/- or -/-


Related Discussions:- Tumor suppressor genes

Explain prophylaxis - fungal infection, Prophylaxis   High-risk neutrope...

Prophylaxis   High-risk neutropenic patients, such as those undergoing allogeneic and certain autologous stem cell transplants, and those with hematologic malignancy who are exp

Explain the glass test tubes - food microbiology, Explain the Glass Test Tu...

Explain the Glass Test Tubes - Food Microbiology Sterile glass tubes are used for culturing microorganisms in liquid or solid media. Sterility in tubes is maintained by using c

What is hemoglobin s, Question 1 What is megalobastic anemia? Discuss brie...

Question 1 What is megalobastic anemia? Discuss briefly its lab diagnosis. How would you differentiate megaloblastic anemia from other anemias? Question 2 What is hemog

Describe coronary spasm, Q. Describe Coronary Spasm? Usually spasm deve...

Q. Describe Coronary Spasm? Usually spasm develops at the site of subcritical or critical stenoses, but it may also occur in angiographically normal coronary arteries, the so c

How does iodine kill germs, How does iodine kill germs? The microbiocid...

How does iodine kill germs? The microbiocidal action of Iodine is because of the active form, I2, which is polarized by water and like all halogens (chlorine, fluorine, bromine

Winter stratification - thermal stratification, Winter Stratification - The...

Winter Stratification - Thermal stratification During extremes of winter the surface layer of the lake freezes or attains a temperature close to 0° Celsius. Under these condit

Explain class mammalia in animal kingdom, Explain Class Mammalia in animal ...

Explain Class Mammalia in animal kingdom? Class Mammalia: Mammals are distinguished by their hair and their mammary glands. Mammary glands, after which this group of vertebrate

The excretion by the human kidney, The excretion by the human kidneys 1...

The excretion by the human kidneys 1. Descending limb of Loop of Henle is impermeable to water 2. Distal convoluted tubule is incapable of reabsorbing HCO3 3. Nearly 99 p

Physical map, Physical map is the map of locations of the identifiable lan...

Physical map is the map of locations of the identifiable landmarks on DNA (for example restriction of the enzyme cutting sites, genes), regardless of their inheritance. Distance i

Potassium (k) - macronutrients, Potassium (K) - Macronutrients The mai...

Potassium (K) - Macronutrients The main source of K + for plants comes from withering of K containing minerals. Potassium released by withering dissolves in the soil solution

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd