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Tumor Suppressor Genes
Tumor suppressor genes or anti-oncogenes generally inhibit cell division in cooperation with proto-oncogenes. The very existence of these genes prevents cells from undergoing neoplastic transformation. While tumor suppressor genes are inactivated by mutations or are deleted, the absence of their protein products permits malignant growth to occur. The most extensively studied disease caused through suppressor genes is the childhood tumor retinoblastoma (cancer of the retina). The gene included is Rb and the genotype of normal individuals is Rb/Rb. A prerequisite of tumor creation is the development of homozygosity or heterozygosity of the rb allele. The possible genetypes for retinoblastoma are, hence, rb/rb; rb/- or -/-
Explain Subclavian Flap Aortoplasty ? Initial steps are same as for resection and end-to-end anastomosis. After exposing a the entire length of intra thoracic segment of left s
Carpentier: Edwards or similar annuloplasty ring is then sutured into place by interrupted sutures to support the repair and reduce the annulus to a measured amount. The ring m
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Interrupted suture technique: Synthetic braided 2 '0' sutures (ethibond) with 17mtn needles on either end and a pledget is used. Alternate green and white sutures are taken aft
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What are the principal sources of of excessive nitrate and phosphatebin rivers and lakes?
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The major component of food is protein. The proteins ingested as part of our diet are not the same proteins required by the body, nor can large molecules be absorbed from the gut.
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