Tumor suppressor genes, Biology

Assignment Help:

Tumor Suppressor Genes

Tumor suppressor genes or anti-oncogenes generally inhibit cell division in cooperation with proto-oncogenes. The very existence of these genes prevents cells from undergoing neoplastic transformation. While tumor suppressor genes are inactivated by mutations or are deleted, the absence of their protein products permits malignant growth to occur. The most extensively studied disease caused through suppressor genes is the childhood tumor retinoblastoma (cancer of the retina). The gene included is Rb and the genotype of normal individuals is Rb/Rb. A prerequisite of tumor creation is the development of homozygosity or heterozygosity of the rb allele. The possible genetypes for retinoblastoma are, hence, rb/rb; rb/- or -/-


Related Discussions:- Tumor suppressor genes

Explain factors that alter the speed of enzymatic recations, What are the m...

What are the main factors that alter the speed of enzymatic reactions? The major factors that change the speed of enzymatic reactions are temperature, pH and substrate concentr

How different are the ureotelic and the uricotelic excretion, Comparing tox...

Comparing toxicity and the requirement for dilution in water how different are the ureotelic and the uricotelic excretions? What are some examples of animals that present these res

Determine the term -stolon, Determine the term -Stolon. In a number of ...

Determine the term -Stolon. In a number of colonial cnidarians, ascidians, and lophophorans, a cord of tissue connects different zooids of colony to each other. Buds on stolon

Stages of wilms tumour , Stages of Wilm's tumour  We shall now discuss...

Stages of Wilm's tumour  We shall now discuss about the various stages of Wilm's tumour. The extent of  disease is staged according to the findings of  surgery and  the presen

What is the role of Naupliar eye, What is the role of Naupliar eye? The...

What is the role of Naupliar eye? The unique eye found in larval stage of the crustacean life cycle. This single compound eye is located medially, and with exception of copepod

Ask, what are the names of karyotypes?

what are the names of karyotypes?

Chiropterophily - cross-pollination, Chiropterophily - Cross-pollination ...

Chiropterophily - Cross-pollination Pollination brought about by bats is called cheiropterophily. Bats which feed at night and do not see very well, are frequent pollinators i

Blood circulation and respiration, A person is declared to be dead upon the...

A person is declared to be dead upon the irreversible cessation of spontaneous body functions: brain activity, or blood circulation and respiration. However, only about 1% of a per

Ganglia - organisation of nervous system, Ganglia - Organisation of Nervous...

Ganglia - Organisation of Nervous System In between higher non-chordates with a central nervous system, you will observe that the association neurons and motor neurons are con

Find out risk factors for coronary disease, Q. Find out risk factors for co...

Q. Find out risk factors for coronary disease? 1) Tobacco Smoking, the single most preventable cause of death is a leading risk factor for CAD, cerebrovascular accident and

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd