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Tumor Suppressor Genes
Tumor suppressor genes or anti-oncogenes generally inhibit cell division in cooperation with proto-oncogenes. The very existence of these genes prevents cells from undergoing neoplastic transformation. While tumor suppressor genes are inactivated by mutations or are deleted, the absence of their protein products permits malignant growth to occur. The most extensively studied disease caused through suppressor genes is the childhood tumor retinoblastoma (cancer of the retina). The gene included is Rb and the genotype of normal individuals is Rb/Rb. A prerequisite of tumor creation is the development of homozygosity or heterozygosity of the rb allele. The possible genetypes for retinoblastoma are, hence, rb/rb; rb/- or -/-
Q. Pathophysiology of constrictive pericarditis? Ans. The thickened and rigid pericardium causes constriction of the heart and restricts ventricular dialatation and diasto
Explain some Do's and Don'ts when working in Laboratory? 1) Always wear a lab coat when working a laboratory. 2) Ensure that no harm is caused to yourself or the people work
There are two main sources of pollution: (1). Natural Sources: (a) Volcanic ash (b) Marsh gas (CH4) released from decay of organic matter.
Define the Quantitative Analysis in Nutritional Biochemistry? Quantitative analysis involves the measurement of the amount of a substance present. This measurement can be done
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Bacteria: Bacteria have a protective covering called 'cell wall'. Beneath this. there is a plasma membrane which encloses protoplasm of the bacterium containing various types
How much ampicillin (sodium sal, mw=371.40) would you dissolve in 400 mL of water to make 80 mg/ml solution of ampicillin?
EVIDENC E IN FAVOUR OF THE MUTATION THOERY - Mutation theory can explain both progressive and retrogressive evolution and the occurrence of both changed and unchanged forms.
assignment on prolactin
The citric acid cycle functions in the mitochondria of eukaryotes and in the cytosol of prokaryotes. The Succinate dehydrogenase, the only membrane-bound enzyme in t
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