Tumor suppressor genes, Biology

Assignment Help:

Tumor Suppressor Genes

Tumor suppressor genes or anti-oncogenes generally inhibit cell division in cooperation with proto-oncogenes. The very existence of these genes prevents cells from undergoing neoplastic transformation. While tumor suppressor genes are inactivated by mutations or are deleted, the absence of their protein products permits malignant growth to occur. The most extensively studied disease caused through suppressor genes is the childhood tumor retinoblastoma (cancer of the retina). The gene included is Rb and the genotype of normal individuals is Rb/Rb. A prerequisite of tumor creation is the development of homozygosity or heterozygosity of the rb allele. The possible genetypes for retinoblastoma are, hence, rb/rb; rb/- or -/-


Related Discussions:- Tumor suppressor genes

Can you explain process of ovulation, Q. What are the hormones that promote...

Q. What are the hormones that promote the release of the female gamete from the follicle and at which day of the menstrual cycle does this phenomenon happen? What is this event cal

Express the term - aboral surface, In radially symmetric animals there is n...

In radially symmetric animals there is no posterior, or anterior, right sides to the animal. Rather we refer to two sides of the animal by referring to the location of the mouth. I

Bovine rotavirus diarrhoea, Bovine rotavirus diarrhoea The bovine rota...

Bovine rotavirus diarrhoea The bovine rotavirus is a RNA virus with 11 segments of double stranded RNA belonging to the genus Rotavirus in the family Reoviridae. Rotaviruses c

Describe class ophiuroidea in general way, Describe Class Ophiuroidea in ge...

Describe Class Ophiuroidea in general way? Brittle stars have a central disc with five long, thin, flexible arms that can be detached from the body at will in times of danger.

Name two stimulant drugs, Name two stimulant drugs and state the undesirabl...

Name two stimulant drugs and state the undesirable side-effects of each. Amphetamine and cocaine are stimulant drugs. The side-effects of amphetamines are high blood pressure;

Biology in ancient india, BIOLOGY IN ANCIENT INDIA - L A T E STONE ...

BIOLOGY IN ANCIENT INDIA - L A T E STONE AGE [10,000 - 20, 000 B.C) Man first cultivated wheat, barley, lentils & peas. In India rice was first cultivated at Meherga

Homework, The Waldorf family was caught in a fire but escaped. Unfortunatel...

The Waldorf family was caught in a fire but escaped. Unfortunately, the father and daughter suffered burns. The father had second-degree burns on his entire chest, abdomen, and bot

Explain concept of digestion of proteins, Digestion of Proteins The pr...

Digestion of Proteins The proteolytic enzymes secreted  by  gastric juice, pancreatic juice  and  intestinal juice cause the hydrolysis of proteins in  the gastrointestinal tra

Determine energy expenditure for climbers, Determine energy expenditure for...

Determine energy expenditure for Climbers? The energy expenditure of 3250 Kcal/ day is reported in climbers to Mt. Everest using doubly labeled water teaching. Out of this, 161

Clinical features - infective endocarditis, The clinical  manifestations of...

The clinical  manifestations of IE result from the local destructive effects of intracardiac infection; the embolization of bland or septic fragments of vegetations to

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd