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Tumor Suppressor Genes
Tumor suppressor genes or anti-oncogenes generally inhibit cell division in cooperation with proto-oncogenes. The very existence of these genes prevents cells from undergoing neoplastic transformation. While tumor suppressor genes are inactivated by mutations or are deleted, the absence of their protein products permits malignant growth to occur. The most extensively studied disease caused through suppressor genes is the childhood tumor retinoblastoma (cancer of the retina). The gene included is Rb and the genotype of normal individuals is Rb/Rb. A prerequisite of tumor creation is the development of homozygosity or heterozygosity of the rb allele. The possible genetypes for retinoblastoma are, hence, rb/rb; rb/- or -/-
Clostridium perfringens infections Cl. perfringens is a rod-shaped, spore-bearing anaerobic organism. It is capsulated and non-motile. A characteristic feature of the organism
In humans, starch digestion begins in the buccal cavity but stops in the Stomach. Why? Name the two most biodiversity-rich zones of India. Name the hormone that makes the p
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Birth Marks (Naevi): Birth Marks is also known as naevi. It is a multiplication of one or more cutaneous elements within the skin. It is defined as a congenital, ci
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Explain Clinical stigmata of specific syndromes in heart disease? Clinical stigmata of specific syndromes: Evidence of preseilce of chromosoinal anomalies or other syndromes
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