Tumor suppressor genes, Biology

Assignment Help:

Tumor Suppressor Genes

Tumor suppressor genes or anti-oncogenes generally inhibit cell division in cooperation with proto-oncogenes. The very existence of these genes prevents cells from undergoing neoplastic transformation. While tumor suppressor genes are inactivated by mutations or are deleted, the absence of their protein products permits malignant growth to occur. The most extensively studied disease caused through suppressor genes is the childhood tumor retinoblastoma (cancer of the retina). The gene included is Rb and the genotype of normal individuals is Rb/Rb. A prerequisite of tumor creation is the development of homozygosity or heterozygosity of the rb allele. The possible genetypes for retinoblastoma are, hence, rb/rb; rb/- or -/-


Related Discussions:- Tumor suppressor genes

Describe valvular ps murmur and their characterstics, Describe Valvular PS ...

Describe Valvular PS Murmur and their characterstics? Characteristic: Harsh crescendo-decrescendo murmur along the left sternal border and loudest at pulmonary area, conducted

Valves of the heart, Valves of the Heart There are four valves which ...

Valves of the Heart There are four valves which are flap-like structures that function to maintain unidirectional (forward) blood flow through the heart chambers. These va

Explain elements of xylem in gymnosperms, The chief water conducting elemen...

The chief water conducting elements of xylem in gymnosperms are: 1. Vessels 2. Fibres 3. Transfusion tissue 4. Tracheids Tracheids

Describe the the growth of the plants in the 2 groups, There has not been r...

There has not been rain for several months. A biologist is driving down the highway and notices that a large number of corn fields have corn that is wilted and short. She wonders i

Define protection of poly unsaturated fatty acids, Define Protection of pol...

Define Protection of poly unsaturated fatty acids (PUFA) from oxidative damage? The major biological role of vitamin E is to protect PUFAs and other components of cell membrane

Explain keshan disease caused by selenium deficiency, Explain Keshan diseas...

Explain Keshan disease caused by Selenium deficiency? It is a cardiomyopathy (disease of the myocardium, involving heart muscle) that was identified to affect children and wome

Differences of transposable elements in e. coli, Discuss the similarities a...

Discuss the similarities and differences of transposable elements in E. coli, yeast, plants, and Drosophila.

Which part of the skin is the pigment injected, Permanent tattoos are made ...

Permanent tattoos are made by injecting pigment into the skin. Into which part of the skin is the pigment injected, the epidermis or dermis?

Define microscopical examination of starch granules, Define Microscopical E...

Define Microscopical Examination of Starch Granules? Take a slide and make a thin film of a suspension of starch granules from different sources and examine under a microscope.

Determine a testable hypothesis, A friend of yours suggests that the origin...

A friend of yours suggests that the origin of life on earth is extraterrestrial in origin (an idea known as panspermia). Can you propose a testable hypothesis to determine if this

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd