Tubercular meningitis , Biology

Assignment Help:

Tubercular Meningitis (TBM)

Tubercular meningitis is a serious complication of childhood tuberculosis. It usually occurs secondarily to primary infection with tuburculosis. It may appear within one year of primary infection with tuberculosis and may lead serious disabling neurological sequelae.

Pathophysiology

The tubercular meningitis result due to hematogenous spread from primary leison. A submeningial tuberculoma may form which discharges tubercle bacilli in the subarachnoid space. The bacilli proliferate and cause perivascular exudation followed by caseation, gliosis and giant cell formation.

The meningial surface is covered with yellow greyish tubercles, usually along the course of the vessels which are more numerous in temporal lobe and along the course of middle cerebral artery. The ventricles get dilated resulting in obliteration of subarachnoid space and the arachnoid villi leading to increase in formation of cerebrospinal fluid. The foramina also get blocked with gelatinous exudate which interferes with CSF circulation and causes hydrocephalus. There is cereberal oedema which results in tuberculous encephalopathy.


Related Discussions:- Tubercular meningitis

Role of glucose-6-phosphate dehydrogenase - gene expression, Define Role of...

Define Role of Glucose-6-phosphate dehydrogenase - Gene Expression? Glucose-6-phosphate dehydrogenase (G6PD) is another enzyme involved in lipogenesis that is regulated by diet

What is the crystallization of a virus, Q. What is the crystallization of a...

Q. What is the crystallization of a virus? What is the significance of this process? Crystallization is the procedure of transformation of viral components into organized solid

What is the function of the skin in humans, Q What is the function of the s...

Q What is the function of the skin in humans? The skin is the external covering of the body. In humans its major functions are protection and perception of information from the

Describe binding of two amino acid for peptide formation, How can the bindi...

How can the binding of two amino acids for the peptide formation be described? A peptide is formed when a carbon from the carboxyl group of one amino acid is linked to the nitr

What is photoperiod, What is photoperiod? Photoperiod is the daily time...

What is photoperiod? Photoperiod is the daily time period of light exposure of a living being. The photoperiod might be vary according to the period of the year.

Define distribution of body iron in different compartments, Define Distribu...

Define Distribution of body iron in different compartments? In humans, the total quantity of iron in the body varies with haemoglobin concentration, body weight, gender and the

Advantages and disadvantages of organizational charts, Advantages and Disad...

Advantages and Disadvantages: of Organizational Charts Advantages  a)  Defining the Organizational Relationship Without a,chart, many people might view the organization as

Explain senning procedure, Explain Senning Procedure ? Operation is per...

Explain Senning Procedure ? Operation is performed by ascending arteries and separate SVC and IVC cannulation. If the operation is done under deep hypothermic circulatory arres

Describe schizocoelus and its role., Describe Schizocoelus and its role. ...

Describe Schizocoelus and its role. One of two ways that a body cavity forms within mesoderm. (The other is enterocoelic pouching.) Block of mesoderm splits apart to create the

The statement is true or false, Anton van Leeuwenhoek was the first to prop...

Anton van Leeuwenhoek was the first to propose placing microorganisms into the Kingdom Monera. True or False

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd