Transcription factors have multiple domains, Biology

Assignment Help:

In most cases, the transcription factors in eukaryotes which bind to promoter   or enhancer sequences   are activator   proteins   which induce   transcription.   That proteins generally have at least two distinct domains of protein structure, a DNA- binding  domain  which identify  the specific DNA sequence  to bind to and an activation  domain responsible  for bringing  about the transcriptional  activation by  interaction  with  other  transcription   factors  and the  RNA  polymerase molecule. Various transcription factors operate as dimers, either homodimers (identical subunits) or heterodimers (dissimilar subunits) with the subunits held together through dimerization domains. The DNA dimerization domains and binding domains have characteristic protein structures (motifs) which are explained2440_22.png

Figure: Looping out of DNA permitting the interaction of enhancer-bound factor(s) with the transcription initiation complex.

below. At last, some transcription factors example for steroid hormone receptors are responsive  to specific  short  molecules  (ligands)  that  regulate  the activity  of the  transcription  factor.  In these cases, the ligand binds at a ligand-binding domain.


Related Discussions:- Transcription factors have multiple domains

Explain tuberculosis, Tuberculosis Tuberculosis is a chronic infectious...

Tuberculosis Tuberculosis is a chronic infectious disease which is caused by a bacterium - Mycobacterium tuberculosis.  It affects the lungs most commonly but call gel localize

Determine the causal factors of nervous system, Determine the Causal factor...

Determine the Causal factors of nervous system Although, the brain and spinal cord are surrounded by tough membranes, enclosed in the bones of the skull and spinal vertebrae, a

Phase (different interference) contrast microscopy, Phase (different interf...

Phase (different interference) Contrast microscopy: Living cells are mostly   transparent. For viewing under ordinary light microscope, therefore, live cells must be stained wi

Reasons for increasing popularity of dental implants, Q. Reasons for increa...

Q. Reasons for increasing popularity of dental implants? There are various reasons for increased popularity of dental implants. With the rapid development and evolution of impl

Explain the future challenges for neuroscience, Explain the Future challeng...

Explain the Future challenges for Neuroscience? When the analysis of single cells and even networks has progressed very nicely, there still remain many significant questions. A

Observing root hairs, Observing root hairs Study the root hairs with a ...

Observing root hairs Study the root hairs with a hand lens and view how they are constructed.

Lymphatic obstruction leading to heart failure?, A 62 year old white male d...

A 62 year old white male develops pitting edema of both feet. Put on Lasix and metoprolol. Develops hallucinations and confusion. Tapered off. Dies 3 weeks later of lymphatic o

Human activity lead to the extinction of a species, In what ways could huma...

In what ways could human activity lead to the extinction of a species in an area? Human activity could lead to extinction of a species by (a) over-hunting, e.g. elephants, rhin

Signify the term - proglottids, Signify the term - Proglottids? Seriall...

Signify the term - Proglottids? Serially repeating segment like structures found in tapeworms which contain reproductive organs. Immature proglottids are continually added at t

Inhibition of microbes by weak acids, With the exception of those soft drin...

With the exception of those soft drinks that contain phosphoric acid, in most other acidic foods acidity is due to the presence of weak organic acids. These do not dissociate comp

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd