The fragility of erythrocytes, Biology

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The fragility of erythrocytes

The fragility of erythrocytes is impaired in the absence of NADPH generation due to the deficiency of glucose-6-phosphate dehydrogenase thereby causing haemolytic anaemia when the  red blood cells are  subjected  to certain drugs  such as primaquine and sulphonamide. An inverse correlation has been found between  the activity of glucose- 6-phosphate dehydrogenase and  the fragility  of  red cells  (i.e. susceptibility  to  haemolysis).

 


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