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S-Adenosyl methionine serve as a donor of methyl sets in numerous biological reactions instance for in the formation of creatine phosphate and in the synthesis of nucleic acids. It is formed by the action of the activated methyl cycle. In during donation of its methyl group to another compound, S-adenosyl methionine is altered into S-adenosyl homocysteine. To reproduce S-adenosyl methionine, the adenosyl group is deleted from the S- adenosyl homocysteine to form homocysteine. This is then methylated by the enzyme homocysteine methyltransferase, only two vitamin B12- holding enzymes found in eukaryotes, to form methionine. The concluded methionine is then activated to S-adenosyl methionine with the release of all three of the phosphates from ATP.
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