Supportive evidence - erythema marginatum, Biology

Assignment Help:

Minor Criteria

These are arthralgia, fever, prolonged PR interval, raised ESR and C-reactive protein levels. In some cases abdominal pain and epistaxis may occur. Other non specific laboratory findings are leucocytosis and anaemia.

Supportive Evidence

One must always look for supportive evidence for antecedent GAS infection in form of positive throat culture, rising ASO titres, and rapid streptococcal antigen tests.  Various antibody tests carried out are anti-streptolysin O, anti-deoxyribonuclease B (ADNaseB), anti-nicotinamide adenosine dinucleotidase (ANA Dase), anti-hyaluronidase and anti-streptokinase.

When two serum samples taken at 2-4 weeks intervals show a two-fold rise, antibody tests are considered positive. The ASO titres of > 250 Todd units in adults and > 333 Todd Units in children are considered positive. The ASO titres may take upto 4-6 months to return to normal, hence by the time chorea or carditis develops after ARF, ASO titres may have returned to normal. In such situation, one may rely on ADNase B levels, as it remains elevated even beyond 6 months after ARF. Diagnosis of ARF is confirmed if 2 major or one major and 2 minor Jones criteria are present along with a supporting evidence of GAS pharyngitis.


Related Discussions:- Supportive evidence - erythema marginatum

A fruit fly has four pairs of chromosomes in its cells, A fruit fly has fou...

A fruit fly has four pairs of chromosomes in its cells. At meiosis, how many dissimilar combinations of maternal and paternal chromosomes are possible in the gametes? In gamet

Cleavage - metazoa, Cleavage - Metazoa The unicellular zygote begins c...

Cleavage - Metazoa The unicellular zygote begins cell division (cleavage). First, the single cell divides forming two cells, these redivide further to form four, then eight ce

Management of asymptomatic patient, Q. Management of Asymptomatic Patient? ...

Q. Management of Asymptomatic Patient? The most common cause of death in a truly asymptomatic patient with severe aortic stenosis is aortic valve replacement (AVR). While expec

Define functional role of sugars in food, Define Functional Role of Sugars ...

Define Functional Role of Sugars in Food? From the consumer's point of view, sugars are basically related with sweetness. Sweetness is essentially a physiological sensation. Th

Ecosystem control, Ecosystem Control Another important aspect of ecosy...

Ecosystem Control Another important aspect of ecosystem functioning that is how it maintains its ecological balance. By now, it must be obvious to you that an ecosystem is a d

Explain adverse effects of zidovudine, Explain Adverse effects of Zidovudin...

Explain Adverse effects of Zidovudine  It include anemia, neutropenia, nausea, vomiting, headache, fatigue, confusion, malaise, myopathy, hepatitis, and hyperpigmentation of or

Describe the developmental periods of coronary artery diseas, Describe the ...

Describe the Developmental Periods of coronary artery diseases? The development of coronary artery disease like many other diseases can be divided into the following periods:

What is protein synthesis, What is Protein Synthesis? Protein Synthesi...

What is Protein Synthesis? Protein Synthesis :  Protein synthesis begins in the nucleus, with the formation of mRNA from a DNA template through transcription. The function of

Define role of thiamin in the conversion carbohydrate to fat, Define the Ro...

Define the Role of Thiamin in the conversion carbohydrate to fats? Thiamin helps in the initial steps of fatty acid and sterol production. In this way, thiamin also helps co

The digestive system, fat digestion requires two steps, what are the steps ...

fat digestion requires two steps, what are the steps and what enzymes are use to accomplish

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd