Supportive evidence - erythema marginatum, Biology

Assignment Help:

Minor Criteria

These are arthralgia, fever, prolonged PR interval, raised ESR and C-reactive protein levels. In some cases abdominal pain and epistaxis may occur. Other non specific laboratory findings are leucocytosis and anaemia.

Supportive Evidence

One must always look for supportive evidence for antecedent GAS infection in form of positive throat culture, rising ASO titres, and rapid streptococcal antigen tests.  Various antibody tests carried out are anti-streptolysin O, anti-deoxyribonuclease B (ADNaseB), anti-nicotinamide adenosine dinucleotidase (ANA Dase), anti-hyaluronidase and anti-streptokinase.

When two serum samples taken at 2-4 weeks intervals show a two-fold rise, antibody tests are considered positive. The ASO titres of > 250 Todd units in adults and > 333 Todd Units in children are considered positive. The ASO titres may take upto 4-6 months to return to normal, hence by the time chorea or carditis develops after ARF, ASO titres may have returned to normal. In such situation, one may rely on ADNase B levels, as it remains elevated even beyond 6 months after ARF. Diagnosis of ARF is confirmed if 2 major or one major and 2 minor Jones criteria are present along with a supporting evidence of GAS pharyngitis.


Related Discussions:- Supportive evidence - erythema marginatum

Define economically important fermentation products, Normal 0 f...

Normal 0 false false false EN-US X-NONE X-NONE MicrosoftInternetExplorer4

Explain the body tube of microscope, Explain the Body Tube of Microscope? ...

Explain the Body Tube of Microscope? Above the stage and attached to the arm is the body tube, to which eye piece(s) or ocular lens and revolving nosepiece is attached. Microsc

What is protein denaturation, What is protein denaturation? Is there any ch...

What is protein denaturation? Is there any change in the primary structure when a protein is denatured? Secondary, tertiary and quaternary structures of proteins are spatial st

What is represented by the cellular secretion, Q. What is represented by th...

Q. What is represented by the cellular secretion? Cell secretion is the removal to the exterior of substances produced by the cell for instance, hormones, mucus, and sweat, so

Define fish as a rich source of protein, Define Fish as a rich source of pr...

Define Fish as a rich source of protein? The edible portion is skeletal muscles of the body. Even though the skeletal muscles of different animals are basically similar, fish s

What is the action mechanism of the antibiotic penicillin, Penicillin, disc...

Penicillin, discovered by the Scottish doctor Alexander Fleming, in 1928, is a drug that inhibits enzymes essential for the synthesis of peptidoglycans, a constituent of the bacter

Clinical manifestations of maple syrup urine disease, Q. Clinical manifesta...

Q. Clinical manifestations of maple syrup urine disease? Clinical manifestations are expressed upon protein loading or with febrile illness. In most severely impaired enzyme de

Define the microbiological study of water, Define the Microbiological Study...

Define the Microbiological Study of Water? Water is a common carrier of infectious diseases. Even clean and clear water which looks pure may be contaminated with pathogenic mic

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd