Stereochemistry , Chemistry

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1. Alcohols and amines are both nucleophilic. Explain why this reaction occurs to form Benadryl (diphenhydramine)

708_alcohol.png

2. Outline a reasonable synthesis of the following:

318_synthesis 2.png

3. Complete the short synthesis below by providing the necessary reagents.

2434_synthesis 1.png

4. An SN2 reaction is characterized by inversion of configuration. Propose a sequence that would allow the preparation of the nitrile derivative B from bromide A. Note that there is no change in the overall stereochemistry of the product. More than one step may be required to complete the sequence.

 

911_synthesis.png

5. Provide structures for compounds A-E, which are formed in the following reactions. Pay attention to stereochemistry where appropriate.

 

 

1618_stereochemistry.png


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