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All the cells present in the body contain genes and an approach targeted to modulate the expression of genes is known as gene therapy. This novel approach has emerged by the end of 20th century and comes up with a promise of treating a large number of genetic disorders by ultimately modifying the gene expression (Jin et al, 2008). The two forms of gene therapy are somatic and germ line.
Somatic gene therapy: During this therapeutic approach, the genetic diseases are treated by inserting recombinant genes into non-reproductive or somatic cells. This kind of approach is limited to the patient and does not get transmitted to the future generations of. A normal copy of the malfunctioning gene is inserted into the mutant cells due to which an improvement in the disease phenotype is observed (Dorin, 1996). In the recent past, this technique has been found to be successful in case of familial hypercholesterolaemia and adenosine deaminase deficiency. For treating these disorders hepatocytes and T cells have been used for gene transfer respectively (Dorin, 1996). It has also shown significant success in case of cystic fibrosis and cancer. Various vehicles, like viral and non viral vectors help in the introduction of the genetic material into the mutated cells (Elias and Annas, N.D). This therapeutic approach is categorized into three sections:
However this approach produces short term results as the tissues die and get replaced with other cells.
Based on your reading of the article "New Life for Ancient DNA" which of the following is a false statement in regards to the comparison among genes in extinct and living species?
What is the photoperiod? The Photoperiod is the daily time period of light exposure of a living being and the photoperiod may differ according to the period of the year.
Preoperative antibiotics Preoperative antibiotics can decrease the incidence of infection after colorectal surgery; for elective operations, an oral regimen of neomycin (not a
Which of the following is true for active hyperemia, a local control mechanism within the circulatory system? A. There will be a decrease in force developed by smooth muscles s
#question.give the classes of protozoa phylum in detail with examples .
Define Diarrhoea problem of infants & preschoolers nutrition? We have just covered control and strategies in diarrhoea management in the above section. Crawling, unclean hands,
How can we control to occur Campylobacteriosis diseases If a person is suffering from campylobacteriosis, he can take an antibiotic such as ciproflaxin or azithromycin. Erythro
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Why in the preparation of a karyotype analysis is the use of a substance like colchicine interesting? The Colchicine is a substance that disallows the formation of microtubules
what arachnid is beneficial
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