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Sickle cell anaemia in man is caused by a defective chain of haemoglobin. The abnormal haemoglobin known as MbS differs from natural haemoglobin (HhA) in one amino acid. A substitutional mutation causes the replacement of glutamic acid by valine in the sixth position from the amino terminal end of the Q chain polypeptide. This is because instead of the triplet GAA or GAG which codes for glutarnic acid in normal chains, the abnormal mRNA has GUA or GUG which codes for valine. IdbS in deoxygenated state precipitates out of solution forming elongate crystals. 'The formation of crystals in turn produces a characteristic deformation of RBCs and the cells acquire a crescent or sickle shape, hence the name sickle cell anaemia. The deformation of red cell weakens the red cell membrane and lyses the cells. The loss of red cells and haemoglobin leads to anaemia and this causes oxygen deficiency to the tissues per unit time. Pt, single substitution, more specifically, replacing the thymine by adenine in the second position of the sixth triplet of the P chain gene triggers a variety of responses that affects several aspects of the pfnysiology of the organism. Individuals who are homozygous (HbSiHbS) for the gene usually die early in life. In heterozygotes some proporrion of red cells lyse periodically but this does not cause any serious harm to the individual and in any case the survival is not affected.
A transport process in which physical (hydrostatic) pressure drives part of a fluid through a membrane that selects based on pore size
Q. What are the two main species of taenias that cause human diseases? The two chief species of taenias that cause disease in humans are Taenia solium, or the pork tapeworm, an
Pulmonary edema is life-threatening condition and therefore, treated as a medical emergency. As is the case with chronic stable heart failure, identification and correction of any
Define Nutrition and Sports - Physical Fitness of an athlete? The physical fitness and performance of an athlete is affected by both current and previous nutritional status. T
Explain about Fats and oils Fats and oils are a unique class of agricultural products in that a high degree of interchangeability among them is possible for many products and u
Illustrate the electrophysiology and ion transport of cornea? Electrophysiology and ion transport of cornea: The trans-epithelial potential is 25-35 mV. It is almost 50 p
Define Genetic engineering and Biotechnology Genetic engineering or recombinant DNA technology, involves the use of a variety of enzymes, such as restriction endonucleass and
How many cells are in the average human brain? Roughly, 6 trillion are in the average human brain.
what is direct and indirect external respiration
A r se n i c Arsenic is a widely distributed environmental pollutant that gets released into the environment through industrial processes and agricultural usage. Arsenic c
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