Sickle Cell, Biology

Assignment Help:
Sickling occurs in deoxyhemoglobin S, but not in oxyhemoglobin S. Oxyhemoglobin has a small hydrophobic \"pocket\" in a ß chain region located in the interior of the protein. In deoxyhemoglobin, however, this pocket is located on the surface of the protein. In deoxyhemoglobin S, Val 6 interacts with this surface pocket leading to aggregation of HbS. Choose two amino acids that would be reasonable candidates for the pocket-Val 6 interaction.

Related Discussions:- Sickle Cell

What is infra-diaphragmatic type of tapvc, What is Infra-diaphragmatic Type...

What is Infra-diaphragmatic Type of TAPVC? Initial stages of operation are the same as for supracardiac type of TAPVC. The heart is lifted out of the pericardial cavity and c

What is diagnostic wax up, Diagnostic Wax Up A diagnostic wax up should...

Diagnostic Wax Up A diagnostic wax up should be done by you or got done from a laboratory for each and every case regardless of the extent or difficulty level of the case as it

Skeletal biology, What is Skeletal Biology? What is specification of Skelet...

What is Skeletal Biology? What is specification of Skeletal Biology? Describe please.

Why is it necessary to maintain the ph level, Q Coming from the acid pH of ...

Q Coming from the acid pH of the stomach which pH level does the chyme find when it enters the duodenum? Why is it necessary to maintain that pH level in the small intestine? What

Explain about platyhelminth phylum, What are the best known representatives...

What are the best known representatives of the platyhelminth phylum? The most popular representatives of the platyhelminthes are worms that cause human diseases, like taenia an

Describe the features common in ventricular outflow, Describe the Features ...

Describe the Features common in ventricular outflow obstruction ? An ejection systolic murmur (ESM) due turbulent flow of blood through the obstruction. Hypertrophy of the cham

Tolerance range - ecosystem, Tolerance Range - Ecosystem Organisms are...

Tolerance Range - Ecosystem Organisms are able to survive only within certain maximum and minimum limits with respect to each environmental factor such as water, light and tem

Photosynthesis, explain the role of photophosphorylation and chemiosmosis i...

explain the role of photophosphorylation and chemiosmosis in photosynthesis

Explain congenital heart disease, Explain congenital heart disease ? No...

Explain congenital heart disease ? No systematic surveys have been conducted to estimate the incidence of CHD at birth in India and other developing countries. As a result ther

History of plant classification, Q. History of plant classification? Be...

Q. History of plant classification? Before Darwin's theory of evolution and publication of his epoch making work 'Origin of Species' in 1959 no outstanding basis for the classi

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd