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Biological effects: Aflatoxins are acute hepatotoxins and are known to be carcinogenic in some animal species as rat. Aflatoxin B1 is acutely toxic and is responsible for liver necrosis. The toxicological effects of the aflatoxins are influenced by their metabolism after intake into their body.
Figure: Representation of the metabolism of aflatoxin and its biological effects
When cows eat feed containing aflatoxin, aflatoxin M1 and M2 is excreted in the milk. Although M1 and M2 are less toxic than the parent compound B1, M1 retains its toxic and carcinogenic ability in many animals. The LD50 of AFB1 for rats by the oral route is 1.2mg/kg and 1.5 to 2.0 mg/kg for AFG1.
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Write short note on glycogen storage diseases. Glycogen storage diseases are caused by genetic defects that result in deficiencies in certain enzymes of glycogen metabolism.
The Waldorf family was caught in a fire but escaped. Unfortunately, the father and daughter suffered burns. The father had second-degree burns on his entire chest, abdomen, and bot
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Why are the recombinant DNA technology and the nucleus transplantation technology still dangerous? The recombinant DNA technology and the nucleus transplantation technology (cl
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Q. Which kind of polarity do fat-soluble and water-soluble substances respectively have? Ans. Water-soluble substances are behave as polar molecules, i.e., they have e
Prophylaxis Many experts recommend that sexually assaulted adults and adolescents be given treatment to prevent sexually transmitted infections, including therapy for gonorrhea
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