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Biological effects: Aflatoxins are acute hepatotoxins and are known to be carcinogenic in some animal species as rat. Aflatoxin B1 is acutely toxic and is responsible for liver necrosis. The toxicological effects of the aflatoxins are influenced by their metabolism after intake into their body.
Figure: Representation of the metabolism of aflatoxin and its biological effects
When cows eat feed containing aflatoxin, aflatoxin M1 and M2 is excreted in the milk. Although M1 and M2 are less toxic than the parent compound B1, M1 retains its toxic and carcinogenic ability in many animals. The LD50 of AFB1 for rats by the oral route is 1.2mg/kg and 1.5 to 2.0 mg/kg for AFG1.
Necessity of interdependence of Volvox organisms in the colonial existence
Explain Acute Renal failure Acute Renal failure: Renal failure associated with burns or other trauma or with sharp infection or obstruction of the urinary tract.
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