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Biological effects: Aflatoxins are acute hepatotoxins and are known to be carcinogenic in some animal species as rat. Aflatoxin B1 is acutely toxic and is responsible for liver necrosis. The toxicological effects of the aflatoxins are influenced by their metabolism after intake into their body.
Figure: Representation of the metabolism of aflatoxin and its biological effects
When cows eat feed containing aflatoxin, aflatoxin M1 and M2 is excreted in the milk. Although M1 and M2 are less toxic than the parent compound B1, M1 retains its toxic and carcinogenic ability in many animals. The LD50 of AFB1 for rats by the oral route is 1.2mg/kg and 1.5 to 2.0 mg/kg for AFG1.
Q. Can Serotonin used in consciousness? Serotonin complements the action of noradrenalin and acetylcholine in promoting wakefulness and cortical responsiveness. Experiments pro
Complication during gestation Many complications like uterine torsion, vaginal prolapse, mummification, foetal maceration, hydra allantois, hydro amnios and teratological abno
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What are the effects of protease inhibitors? In experimental animals, they have been found to be associated with growth inhibition and pancreatic hypertrophy. A negative feedb
What are holandric genes? The Holandric genes are genes situated in the nonhomologous region of the Y chromosome. Holandric genes condition phenotypes that emerge only in men s
Define Conditions associated with increased need for Vitamin A? Conditions and populations associated with increased need for vitamin A includes young children particularly t
Define Body Mass Index (BMI) or Quetelet Index? BMI is an index measure of body fat used for the assessment of disease risk. It is a figure which gives an indication of weight
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Possible mechanisms of increased risk are that hyperhomocystinemia may impair release of nitric oxide form endothelial cells, stimulate proferation of atherogenic smooth muscle cel
Define Nutritional Management of Paediatric and Geriatric Problems? This unit focused on the paediatric and geriatric problems and their nutritional management.Initially, the c
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