Renin-angiotensin system, Biology

Assignment Help:

As heart failure sets in, there is activation of RAS (Fig 2.1). Adrenergic stimulation of beta-1 receptors in juxtaglomerular apparatus of the kidneys results in release of renin. Another mechanism i.e. responsible for renin release is baroreceptor stimulation in renal vascular bed by reduction of renal blood flow.  

Angiotensin II that is released is a powerful vasoconstrictor and stimulates the release of aldosterone. It also causes remodeling of cardiac myocytes. Aldosterone retains sodium and has direct effects on myocardium. The result is increased systemic vascular resistance and development of edema. Hence the interruption of this renin-angiotensin-aldosterone axis by angiotensin-converting enzyme inhibitors (ACE-Inhibitors) or angiotensin receptor blockers (ARBs) has salutary effects as there is reduction in systemic vascular resistance, afterload reduction, mild diuresis and improvement in the cardiac output.

Angiotensin II also has direct role in modifying the structure and function of myocardium.

2243_Renin-Angiotensin System.png


Related Discussions:- Renin-angiotensin system

Explain the numerical taxonomy, Explain the Numerical Taxonomy? Numeric...

Explain the Numerical Taxonomy? Numerical methods in taxonomy are not new. Simple statistical methods like standard deviations, t-tests and chi-squared have been used for sever

Illustrate target organs of the hormones, Q. What are target organs of the ...

Q. What are target organs of the hormones? Target tissues, Target organs and target cells are those specific organs, cells and tissues upon which each hormone produces and acts

Vasa diffrentia, VAS A DIFFRENTIA - Originate from wollfian duct ....

VAS A DIFFRENTIA - Originate from wollfian duct . It comes out fo cauda epdidymis enters into abdominal cavity through inguinal canal, forms loop round the uretor and j

Define methods of food processing, Define Methods of Food Processing? F...

Define Methods of Food Processing? Food is undeniably most vital to the survival of human beings. Hence, it must be processed using various scientific techniques. This is done

Strain of fusarium moniliforme, Q. Strain of Fusarium moniliforme? It w...

Q. Strain of Fusarium moniliforme? It was first obtained from a strain of Fusarium moniliforme isolated from southern leaf blight- damaged corn seed as a water soluble toxin.

Which is responsible for the positive/negative part of blood, This problem ...

This problem refers to the MN and ABO loci mentioned in class. It also refers to the Rh locus, which is responsible for the positive/negative part of the blood type. The Rh+ allele

Are nematodes exclusively parasites, Are nematodes exclusively parasites? ...

Are nematodes exclusively parasites? There are parasitic roundworms, containing parasites of plants, but there are also free-living nematodes.

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd