Reciprocal translocation and fusion, Biology

Assignment Help:

In chronic myelogenous leukemia, white blood cells proliferate ceaselessly. In affected white blood cells, the BCR-ABL oncogene, the result of a gene fusion, transmits a constitutive growth signal. The severity of the disease correlates with the fraction of white blood cells that carry the BCR-ABL oncogene.

a) How does reciprocal translocation and fusion of the BCR and ABL genes lead to unregulated cell dIvision and leukemia

One treatment for the chronic myelogenous leukemia is a drug that inhibits the BCR-ABL protein and prevents it from transmitting the growth signal. This can result in remission of the disease by preventing proliferation of the cancer cells. During treatment of the disease, the effectiveness of treatment is monitored by assessing the level of the BCR-ABL oncogene present in a fixed quantity of white blood cells. Suppose that the structure of the DNA in the nonmutant BCR and ABL genes are as shown here, and that of the BCR-ABL oncogene is as depicted.

Short oligonucleotide primers that bind to the BCR and ABL genes as shown (the 3' end of each primers is at the tip of the arrow) are labeled 1, 2, 3, and 4.

553_Reciprocal translocation and fusion.png

b) How would you detect the presence of the BCR-ABL oncogene ?

c) If the drug is working, what would you expect to see ?


Related Discussions:- Reciprocal translocation and fusion

How many larvae per treatment, A study is made to verify the effects of pes...

A study is made to verify the effects of pesticide exposure on pupal weight of butterflies. In a pilot study, 5 randomly selected larvae are raised on plants exposed to the pestici

Why this stain have an affinity, Giemsa stain is a basic stain, thus the ma...

Giemsa stain is a basic stain, thus the major chromagen is positively charged (cation). Why does this stain have an affinity for the bacteria cell wall, and for certain cellular co

Explain implant integrity, Explain Implant Integrity Implant Integrity...

Explain Implant Integrity Implant Integrity: A horizontal dark line at the abutment level is most probably due to screw-loosening and separation of elements.  This may happen

Calculate the number molecules of glucose, During a routine annual physical...

During a routine annual physical, a patient was checked to determine the amount of glucose in the blood. After the assay, It was found that the glucose that the glucose concentrati

Explain about the serum vitamin b12 assay, Explain about the Serum vitamin ...

Explain about the Serum vitamin B12 assay? Serum vitamin B 12 assay: The vitamin B 12 content of serum can be determined.  A serum level of 12 deficiency.

Geotropism - root and shoot morphogenesis, Geotropism - Root and Shoot Morp...

Geotropism - Root and Shoot Morphogenesis Roots always grow towards gravity. The lot threshold of geotropic response requires as little time as one minute Gravity pulls auxin

What are gibberellins, What are gibberellins? Where are they produced? ...

What are gibberellins? Where are they produced? Gibberellins are plant hormones that stimulate plant growth, flowering and fruit formation (also parthenocarpy) and the germina

Thyroid, A person has swelling on the front of his neck. Name the disease h...

A person has swelling on the front of his neck. Name the disease he is suffering from and the cause of it.

Morphogenetic movements, Morphogenetic Movements Gastrulation is a dy...

Morphogenetic Movements Gastrulation is a dynamic process including a variety of coordinated movements of cells of dissimilar areas of the blastula. The movements of cells in

Ilustrate the binding of atp to actin, Which of the following is true in a ...

Which of the following is true in a skeletal muscle? A. Movement of the cross-bridge occurs only when the myosin head is detached from the actin molecule. B. The binding of

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd