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The potassium-sparing agents spironolactone, triamterene, and amiloride are often useful in combination with the loop diuretics and thiazides. Triamterene and amiloride act on the distal tubule to reduce potassium secretion. Their diuretic potency is only mild and not adequate for most patients with heart failure, but they may minimize the hypokalemia induced by more potent agents.
Side effects: Hyperkalemia, gastrointestinal symptoms, renal dysfunction and gynecomastia.
Hypodermic-Subcutaneous Injection By this route the drug is mainly absorbed into the blood stream by way of the lymphatic drainage. Absorption is slower by this route
Curdlan Curdlan, a glucan with (1→3) is produced by bacterium Alkaliqenus faecalis var. myogenes and some related bacteria. It is a tasteless, odorless white powder, which sw
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