Polypeptide chains of hemoglobin, Biology

Assignment Help:

Q. In sickle cell anemia, a hereditary disease, there is replacement of one amino acid by another in one of the four polypeptide chains of hemoglobin. In this case are all of the structural levels of the protein modified?

In sickle cell disease there is a modification in the primary protein structure of one of the polypeptide chains that form haemoglobin, the amino acid glutamic acid is substituted by the amino acid valine in the β chain. The spatial conformation of the molecule in addition is also modified and affected by this primary "mistake" and the modification also creates a different (sickle) shape to the red blood cells.

Sickled, Modified, red blood cells sometimes aggregate and obstruct the peripheral circulation causing tissue hypoxia and the pain crisis typical of sickle cell anemia.


Related Discussions:- Polypeptide chains of hemoglobin

Digestion in the intestine, Digestion in the Intestine About  2  to  3 ...

Digestion in the Intestine About  2  to  3  liters  of  alkaline  fluid  is secreted every  day  by  the intestine  and completes the digestive process.  Sodium bicarbonate and

Explain dietetics, Explain Dietetics Dietetics  has been defined as  t...

Explain Dietetics Dietetics  has been defined as  the science and art of feeding individuals based  on the principles of  nutrition. It can also be  said  to  be  the "science

Determine the term - neuropsychological approach, Determine the term - Neur...

Determine the term - Neuropsychological approach The neuropsychological approach relies on the use of tests in which poor performance may indicate either focal (localised) or d

Symptoms of chronic gastritis, Q. Symptoms of chronic gastritis? These ...

Q. Symptoms of chronic gastritis? These include anorexia, chronic fatigue, and feeling of fullness, belching, vague epigastric pain, nausea and vomiting and passage of black ta

Effects of smoking on oesophagitis, Q. Effects of smoking on oesophagitis? ...

Q. Effects of smoking on oesophagitis? 1. A decrease in pyloric sphincter pressure which may predispose an individual to duodenal ulcer. 2. An alteration in the nature of ga

Megaloblastic anaemia, Megaloblastic Anaemia   Megaloblastic anaemia re...

Megaloblastic Anaemia   Megaloblastic anaemia refers to the abnormal development  of red cells i.e. megaloblasts in the bone marrow.  Etiology   It is due to lack of f

Electronic chip is implanted in the body – vivo and vivo, An electronic chi...

An electronic chip is to be implanted in the body. During in vitro (in the lab) testing it is observed that the chip will dissolve over time if exposed to liquid with similar pH to

Guanotelism - excretion, Guanotelism - Excretion Normal ...

Guanotelism - Excretion Normal 0 false false false EN-IN X-NONE X-NONE MicrosoftInternetExplorer4

Absorption, Absorption The monosaccharides, amino acids and other prod...

Absorption The monosaccharides, amino acids and other products of digestion must be passed on to other tissues to be useful for the organism. The process by which the digested

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd