Polypeptide chains of hemoglobin, Biology

Assignment Help:

Q. In sickle cell anemia, a hereditary disease, there is replacement of one amino acid by another in one of the four polypeptide chains of hemoglobin. In this case are all of the structural levels of the protein modified?

In sickle cell disease there is a modification in the primary protein structure of one of the polypeptide chains that form haemoglobin, the amino acid glutamic acid is substituted by the amino acid valine in the β chain. The spatial conformation of the molecule in addition is also modified and affected by this primary "mistake" and the modification also creates a different (sickle) shape to the red blood cells.

Sickled, Modified, red blood cells sometimes aggregate and obstruct the peripheral circulation causing tissue hypoxia and the pain crisis typical of sickle cell anemia.


Related Discussions:- Polypeptide chains of hemoglobin

Integrated approach plus mastering, I recently rented Physiology, An Integr...

I recently rented Physiology, An Integrated Approach and I was looking online because I have to also get the A&P access code and realize I could have rented it too with my book. Is

Morphological differences between monocot and dicot plants, Q. What are the...

Q. What are the major morphological differences between monocot plants and dicot plants? The main separation criteria between monocots and dicots are: number of cotyledons (see

Law of Minimun, What are the examples of Law of Minimum?

What are the examples of Law of Minimum?

Organisation of nervous system, Organisation of Nervous System Nervou...

Organisation of Nervous System Nervous systems are composed of nerve cells or neurons and glial cells. In the latter half of the 19 th century it was strongly believed that

What would the volume for reaction, The component is DNA. The stock concent...

The component is DNA. The stock concentration is 10mg/ml and the final concentration/amount is 25ug. What is the volume for 1 reaction? For 5 reactions?

Organisational behaviour of health care, Organisational Behaviour of Health...

Organisational Behaviour of Health Care The insights provided by the theories of organisational behaviour emphasise the need for the establishment of institutional frameworks

Experiment to test your hypothesis, Deinococcus radiodurans is a bacterium ...

Deinococcus radiodurans is a bacterium that was isolated from cooling ponds in and around nuclear power plants. It is highly resistant to ionizing radiation. Propose an hypothesis

Explain glycolysis, Explain glycolysis? Name the two monosaccharides w...

Explain glycolysis? Name the two monosaccharides which readily enter the glycolytic pathway. Illustrate a diagrammatic sketch of the microscopic view of a mammalian sperm a

Use of aldehydes as chemical sterilant, Q. Use of Aldehydes as chemical ste...

Q. Use of Aldehydes as chemical sterilant? Formaldehyde: widely employed for the fumigation of operation theatres. Glutaraldehyde: commercial preparations are active at

Define the biochemical analysis, Biochemical analysis A basic metabolic...

Biochemical analysis A basic metabolic panel measures sodium, potassium, chloride, bicarbonate, blood urea nitrogen (BUN), magnesium, creatinine, and glucose. It also sometimes

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd