Polypeptide chains of hemoglobin, Biology

Assignment Help:

Q. In sickle cell anemia, a hereditary disease, there is replacement of one amino acid by another in one of the four polypeptide chains of hemoglobin. In this case are all of the structural levels of the protein modified?

In sickle cell disease there is a modification in the primary protein structure of one of the polypeptide chains that form haemoglobin, the amino acid glutamic acid is substituted by the amino acid valine in the β chain. The spatial conformation of the molecule in addition is also modified and affected by this primary "mistake" and the modification also creates a different (sickle) shape to the red blood cells.

Sickled, Modified, red blood cells sometimes aggregate and obstruct the peripheral circulation causing tissue hypoxia and the pain crisis typical of sickle cell anemia.


Related Discussions:- Polypeptide chains of hemoglobin

#titlemicrobiology.., topics relating research on microorganisms and their ...

topics relating research on microorganisms and their application ?

Mode of nutrition , What is the mode of nutrition in fish,human,amoeba,scor...

What is the mode of nutrition in fish,human,amoeba,scorpian & toad

Define determinants of food security - food utilization, Define Determinant...

Define Determinants of Food Security - Food Utilization? It is the proper biological use of food, requiring a diet providing sufficient energy and essential nutrients, potable

How is the nervous system characterized, Q. How is the nervous system chara...

Q. How is the nervous system characterized in beings of the phylum Annelida? How can one compare cephalization in annelids to cephalization in platyhelminthes and nematodes? An

What are the classes of lipoproteins in the blood, Q. What are the classes ...

Q. What are the classes of lipoproteins in the blood? Blood lipids (cholesterol, triglycerides and phospholipids) being insoluble in blood need a ship to travel in our body; it

Determine the change in the amount of intracellular chloride, Determine the...

Determine the change in the amount of intracellular chloride Complete motor neuron is removed from a frog and placed in a large volume of normal physiological saline.  The neur

Explain le compte operation-rev procedure, Explain Le Compte Operation-REV ...

Explain Le Compte Operation-REV Procedure ? This is an alternative type of repair for TGA, VSD and left ventricular outflow obstruction (LVOTQ). In this operation an extrinsic

Genotype for each individual, The allele that causes albinism (p) is recess...

The allele that causes albinism (p) is recessive to the allele for normal pigmentation (P). A normal woman whose father is an albino marries an albino man whose parents are both no

Explain therapy of specific lipid disorders, Q. Explain Therapy of Specific...

Q. Explain Therapy of Specific Lipid Disorders? a) Very high LDL levels usually result from inherited disorders of lipoprotein metabolism and carry a high risk of premature at

What are secondary roots, What are secondary roots? In origin how secondary...

What are secondary roots? In origin how secondary roots differentiate from shoots? Secondary roots are ramifications of the primary (major) root. The secondary roots emerge fro

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd