Polypeptide chains of hemoglobin, Biology

Assignment Help:

Q. In sickle cell anemia, a hereditary disease, there is replacement of one amino acid by another in one of the four polypeptide chains of hemoglobin. In this case are all of the structural levels of the protein modified?

In sickle cell disease there is a modification in the primary protein structure of one of the polypeptide chains that form haemoglobin, the amino acid glutamic acid is substituted by the amino acid valine in the β chain. The spatial conformation of the molecule in addition is also modified and affected by this primary "mistake" and the modification also creates a different (sickle) shape to the red blood cells.

Sickled, Modified, red blood cells sometimes aggregate and obstruct the peripheral circulation causing tissue hypoxia and the pain crisis typical of sickle cell anemia.


Related Discussions:- Polypeptide chains of hemoglobin

Phylum Coelenterata, Phylum Coelenterata characters anc classification

Phylum Coelenterata characters anc classification

Explain the bioavailability of vitamin d, Explain the Bioavailability of Vi...

Explain the Bioavailability of Vitamin D? The nutritional availability of vitamin D is less significant because it can be endogenously produced and retained for long periods by

Ordinary share capital, Ordinary share capital This type of Equity fi...

Ordinary share capital This type of Equity finance is raised from the public from the sale of ordinary shares to the shareholders. This finance is presented to limited compan

What are the part of the musculoskeletal system, Which are the organs that ...

Which are the organs that are part of the musculoskeletal system? The main organs and tissues that are part of the musculoskeletal system in humans are the cartilages, the bone

What is resting membrane potential of a neuron, What is resting membrane po...

What is resting membrane potential of a neuron? What is the function of sodium potassium pumps in maintaining it?

Importance of counselling for diabetic patient, Q. Importance of counsellin...

Q. Importance of counselling for diabetic patient? Diabetes is a life-long illness. Life style modification and precautions taken by the patient can prevent complications and i

Explain autoxidation, Autoxidation It is generally agreed that "autoxid...

Autoxidation It is generally agreed that "autoxidation", that is, the reaction with molecular oxygen via a self - catalytic mechanism, is the main reaction involved  in oxidati

Explain the position of the endospore, Explain the Position of the endospor...

Explain the Position of the endospore? Endospore cannot be stained by ordinary methods such as simple staining and gram staining because these dyes do not penetrate the wall of

Effects of solid waste pollution, The improper handling and transfer of the...

The improper handling and transfer of the solid wastes results in various health and environmental hazards, such as: 1.      Spoilage of landscape: Municipal wastes heap up o

Biology, What are the differences b/w bone and cartiledge

What are the differences b/w bone and cartiledge

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd