Polypeptide chains of hemoglobin, Biology

Assignment Help:

Q. In sickle cell anemia, a hereditary disease, there is replacement of one amino acid by another in one of the four polypeptide chains of hemoglobin. In this case are all of the structural levels of the protein modified?

In sickle cell disease there is a modification in the primary protein structure of one of the polypeptide chains that form haemoglobin, the amino acid glutamic acid is substituted by the amino acid valine in the β chain. The spatial conformation of the molecule in addition is also modified and affected by this primary "mistake" and the modification also creates a different (sickle) shape to the red blood cells.

Sickled, Modified, red blood cells sometimes aggregate and obstruct the peripheral circulation causing tissue hypoxia and the pain crisis typical of sickle cell anemia.


Related Discussions:- Polypeptide chains of hemoglobin

Determine the self-monitoring of blood glucose, Self-Monitoring of Blood Gl...

Self-Monitoring of Blood Glucose (SMBG) In SMBG, patients measure and monitor their blood sugar level by themselves and assess their condition and know the response to the trea

Explain the uses of iso in dairy-type products, Normal 0 false ...

Normal 0 false false false EN-IN X-NONE X-NONE MicrosoftInternetExplorer4

Who is known as father of english botany, Who is known as Father of English...

Who is known as Father of English Botany? William Turner (1515-1568), whose 'A New Herbal' printed in English appeared in 1551 (first part), 1562 (second part) and 1568 (third

Cell, compare and contrast plant cell and animal cell with labeling diagram...

compare and contrast plant cell and animal cell with labeling diagrams

Mention causes of implant failure, Mention causes of implant failure due to...

Mention causes of implant failure due to improper implant selection. Implant selection errors : a) Improper implant type in improper bone type. b) Improper length, width

Animal phylum that contains creatures with analogous organs, Q. Most insect...

Q. Most insects have wings. Which is the other animal phylum that contains creatures with analogous organs? Besides the phylum Arthropoda another animal phylum with flying crea

Vertebrates - osmotic and ionic regulation, Normal 0 false fa...

Normal 0 false false false EN-IN X-NONE X-NONE MicrosoftInternetExplorer4

How do the sodium and potassium ions maintain the neuron, How do the sodium...

How do the sodium and potassium ions maintain the resting potential of the neuron? The plasma membrane of the neuron when at rest maintains an electric potential difference amo

Ecological pyramids - ecosystem, Ecological Pyramids - Ecosystem The a...

Ecological Pyramids - Ecosystem The ancient Egyptians constructed elaborate tombs called pyramids. The base of the pyramid is broad and it supports the upper levels of the str

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd