Polypeptide chains of hemoglobin, Biology

Assignment Help:

Q. In sickle cell anemia, a hereditary disease, there is replacement of one amino acid by another in one of the four polypeptide chains of hemoglobin. In this case are all of the structural levels of the protein modified?

In sickle cell disease there is a modification in the primary protein structure of one of the polypeptide chains that form haemoglobin, the amino acid glutamic acid is substituted by the amino acid valine in the β chain. The spatial conformation of the molecule in addition is also modified and affected by this primary "mistake" and the modification also creates a different (sickle) shape to the red blood cells.

Sickled, Modified, red blood cells sometimes aggregate and obstruct the peripheral circulation causing tissue hypoxia and the pain crisis typical of sickle cell anemia.


Related Discussions:- Polypeptide chains of hemoglobin

Define the term -aqueous movement and outflow, Define the term -Aqueous Mov...

Define the term -Aqueous Movement and Outflow There are two movements of the aqueous humour that occur-thermal flow and bulk flow. Thermal flow is, an internal circulation of

How sugar is used in custards, How Sugar is used in Custards? While flo...

How Sugar is used in Custards? While flour protein forms the structure of baked goods, custards are composed of egg protein structures. If the egg white solidifies too early al

Physiology, using an example in each case,describe the three main feeding m...

using an example in each case,describe the three main feeding methods used by animals based on the type of food available

Acquired immunodeficiency syndrome (aids), Acquired immunodeficiency syndro...

Acquired immunodeficiency syndrome (AIDS) is the collection of disorders which develop as a result of the infection by human immunodeficiency virus (HIV), which attacks the helper

Find the net charge of the predominant form asp, Determine the net charge o...

Determine the net charge of the predominant form Asp at (a) pH 1.0, (b) pH 3.0, (c) pH 6.0, and (d) pH 11.0?

Cardiac transplantation, For patients with end-stage heart failure, cardiac...

For patients with end-stage heart failure, cardiac transplantation has become a promising therapy especially with the advent of  immunosuppressive therapy and more careful screenin

Determine the greater palatine nerve and vessel, Greater Palatine nerve and...

Greater Palatine nerve and vessel  The greater palatine nerve runs forward in a groove on the inferior surface of the hard palate to communicate with nasopalatine nerve in inci

Discuss in detail about the mitochondria, Discuss in detail about the Mitoc...

Discuss in detail about the Mitochondria An important function of the cell is to derive energy from the different oxidisable nutrients, such as, carbohydrates and fats supplied

Similarities in body parts often indicate shared ancestry, Similarities in ...

Similarities in body parts often indicate shared ancestry. Which of the following is true? Structures used for different purposes in different groups can be controlled by the same

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd