Polypeptide chains of hemoglobin, Biology

Assignment Help:

Q. In sickle cell anemia, a hereditary disease, there is replacement of one amino acid by another in one of the four polypeptide chains of hemoglobin. In this case are all of the structural levels of the protein modified?

In sickle cell disease there is a modification in the primary protein structure of one of the polypeptide chains that form haemoglobin, the amino acid glutamic acid is substituted by the amino acid valine in the β chain. The spatial conformation of the molecule in addition is also modified and affected by this primary "mistake" and the modification also creates a different (sickle) shape to the red blood cells.

Sickled, Modified, red blood cells sometimes aggregate and obstruct the peripheral circulation causing tissue hypoxia and the pain crisis typical of sickle cell anemia.


Related Discussions:- Polypeptide chains of hemoglobin

Define serum vitamin a content, Define Serum Vitamin A Content? Assessm...

Define Serum Vitamin A Content? Assessment of serum vitamin A content is the most reliable criterion Tor assessing vitamin A status. Serum levels indicative of various degrees

Name mimicry by which insect mimics insec for protection, From the followin...

From the following, name the type of mimicry by which a palatable, acceptable insect mimics an unfavorable, noxious insec for protection. a) Batesian mimicry (pron: BATE-see-an

Determine the posterior superior alveolar nerves, Determine the posterior s...

Determine the posterior superior alveolar nerves The anterior, middle and posterior superior alveolar nerves run in the facial wall of the maxillary sinus between its lining me

Is the neural impulse generated by the stimulus, Q. Is the neural impulse g...

Q. Is the neural impulse generated by the stimulus that triggers the arch reflex restricted within the neurons of this circuit? This is obvious since the person that received t

Define about the physical fitness, Define about the Physical Fitness? P...

Define about the Physical Fitness? Physical fitness is a general term we come across quite often and use it to describe an individual if he or she is able to carry out a variet

Defina about the lipid metabolism, Defina about the Lipid Metabolism? A...

Defina about the Lipid Metabolism? Animal studies consistently show a hypotriglyceridenlic effect although equivocal results have been seen with healthy humans. Hypotriglycerid

What do you mean by proteinuria, Q. What is proteinuria? Why is proteinuria...

Q. What is proteinuria? Why is proteinuria a sign of glomerular renal injury? Proteinuria means losing of proteins through urine under normal conditions proteins are too big to

Define vitamin a, Define Vitamin A, Iron and Zinc required for elderly? ...

Define Vitamin A, Iron and Zinc required for elderly? Vitamin A, Iron and Zinc: The recommendation for iron is said to decrease in elderly women. Intake of vitamin E and zinc

Euglena, Take the prepared slide of Euglena and focus it first under low po...

Take the prepared slide of Euglena and focus it first under low power and next under the high power of tlie microscope. Observe tlie following characteristics: i) Euglena is an

How were the classification systems of aristotle, How were the classificati...

How were the classification systems of Aristotle and Linnaeus similar?  Both systems divided all living things into two major groups, animals and plants, but Aristotle's system

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd