Polypeptide chains of hemoglobin, Biology

Assignment Help:

Q. In sickle cell anemia, a hereditary disease, there is replacement of one amino acid by another in one of the four polypeptide chains of hemoglobin. In this case are all of the structural levels of the protein modified?

In sickle cell disease there is a modification in the primary protein structure of one of the polypeptide chains that form haemoglobin, the amino acid glutamic acid is substituted by the amino acid valine in the β chain. The spatial conformation of the molecule in addition is also modified and affected by this primary "mistake" and the modification also creates a different (sickle) shape to the red blood cells.

Sickled, Modified, red blood cells sometimes aggregate and obstruct the peripheral circulation causing tissue hypoxia and the pain crisis typical of sickle cell anemia.


Related Discussions:- Polypeptide chains of hemoglobin

Define classification of foods based on ph, Define Classification of foods ...

Define Classification of foods based on pH? Of these, the nature of the food, primarily the pH of food, is the most significant determinant of how severely the food will be pro

Define the nutritional assessment methods, Define the Nutritional assessmen...

Define the Nutritional assessment methods? Nutritional assessment methods commonly used are enumerated herewith. 1. Bodyweight measurement s remain to be the most practical

Explain the proteus - characteristics of bacteria, Explain the Proteus - Ch...

Explain the Proteus - Characteristics of Bacteria? It is gram negative, non-sporulating rod, which is characterized by rapid motility (peritrichous flagella) and swarming type

Which respiratory adaptations or organs do, Q. Which respiratory adaptation...

Q. Which respiratory adaptations or organs do aquatic and terrestrial arthropods respectively present? In crustaceans, typical aquatic beings, there are richly vascularized gil

Explain about the hypokalemia, Explain about the Hypokalemia? Normal s...

Explain about the Hypokalemia? Normal serum K ranges from 3.5-5 mM/L. Hypokalemia or low plasma K levels can occur with a net shift of K from the plasma to the cells. This shi

What is motor neuropathy, What is Motor Neuropathy It leads to muscular...

What is Motor Neuropathy It leads to muscular weakness and wasting.  Muscle wasting leads to various foot deformities and abnormal pressure points develop due to loss of even p

What is the elements of an organic compound, Give an example of how a funct...

Give an example of how a functional group can affect the elements of an organic compound. The hydroxyl group on alcohols is polar and this produces alcohols polar compounds.

Pachytene, Pachytene: The pairing of homologous chromosomes is comp...

Pachytene: The pairing of homologous chromosomes is completed. Chromosomes become more and more thick. Each bivalent has four chromatids , which wrap around each o

What is the treatment of tuberculosis, What is the treatment of tuberculosi...

What is the treatment of tuberculosis The disease can be very effectively treated with the help of antibiotic therapy, rest and nourishing food. The key to the treatment is ear

The genotype of a plant showing the dominant phenotype, The genotype of a p...

The genotype of a plant showing the dominant phenotype can be determined by : 1. Test cross 2. Dihybrid cross   3. Pedigree analysis 4. Back cross It is determined

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd