Polypeptide chains of hemoglobin, Biology

Assignment Help:

Q. In sickle cell anemia, a hereditary disease, there is replacement of one amino acid by another in one of the four polypeptide chains of hemoglobin. In this case are all of the structural levels of the protein modified?

In sickle cell disease there is a modification in the primary protein structure of one of the polypeptide chains that form haemoglobin, the amino acid glutamic acid is substituted by the amino acid valine in the β chain. The spatial conformation of the molecule in addition is also modified and affected by this primary "mistake" and the modification also creates a different (sickle) shape to the red blood cells.

Sickled, Modified, red blood cells sometimes aggregate and obstruct the peripheral circulation causing tissue hypoxia and the pain crisis typical of sickle cell anemia.


Related Discussions:- Polypeptide chains of hemoglobin

Storage excretion, Storage Excretion Many insects exhibit a phenomenon...

Storage Excretion Many insects exhibit a phenomenon known as storage excretion. If excretory products are stored in the body instead of being eliminated, no water is expended

Synthetic petrol, Petrol or gasoline can be synthesized by following three ...

Petrol or gasoline can be synthesized by following three methods: 1.      Polymerisation 2.      Fischer - tropsch method 3.      Bergius process polymerisation In

Procedure of radiographic template, Procedure of radiographic template ...

Procedure of radiographic template It is very similar to a flasking procedure. Mix slow setting irreversible hydrocolloid (alginate) with cold water (to gain more working ti

What is pcr and how does pcr works, What is PCR? How does PCR works? Th...

What is PCR? How does PCR works? The PCR, polymerase chain reaction, is a method to synthesize many copies of specific regions of a DNA molecule known as target-regions. Its in

Define radiological anatomy, Q. Define Radiological anatomy? The border...

Q. Define Radiological anatomy? The borders of the mediastinum on the CXR are defined by the contrast produced by adjacent air filled lung. Postero-Anterior View It in

Plantae, significance of amoebozoa

significance of amoebozoa

Define the gel electrophoresis, Define the Gel Electrophoresis? Gel ele...

Define the Gel Electrophoresis? Gel electrophoresis is among the most powerful and yet conveniently used methods of macromolecular separation. The gels in common use, polyacryl

Clinical manifestations of chronic bronchitis, Clinical Manifestations ...

Clinical Manifestations Early Symptoms Symptoms are episodic in nature or continuous with very little response to bronchodialators. Productive cough especially on awake

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd