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Poisson regression
In case of Poisson regression we use ηi = g(µi) = log(µi) and a variance V ar(Yi) = φµi. The case φ = 1 corresponds to standard Poisson model. Poisson regression is used when the response to model is counts which typically follow a Poisson distribution. Examples include colony counts for bacteria or viruses, accidents, equipment failures, insurance claims, incidence of disease. Interest often lies in estimating a rate of incidence and determining its relationship to a set of explanatory variables. Again, an IRLS procedure is used to ?nd the MLE estimators of the β coeffcients. When we can not assume φ = 1, (this is the case of over- or under- dispersion discussed in McCullagh and Nelder (1989)), the iterative procedure is changed to so called "quasi-likelihood estimation". Finally in this section, we shall also mention shortly the extension of GLM to GAM.
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Historical controls : The group of patients treated in the past with the standard therapy, taken in use as the control group for evaluating the new treatment on the present patient
The Null Hypothesis - H0: γ 1 = γ 2 = ... = 0 i.e. there is no heteroscedasticity in the model The Alternative Hypothesis - H1: at least one of the γ i 's are not equal
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A family of the probability distributions of the form given as here θ is the parameter and a, b, c, d are the known functions. It includes the gamma distribution, normal dis
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